Bipolar Disorder Community
5k Members
Avatar universal

Insight on the neurological side effects from Seroquel and Cymbalta?

HELP?! I'm hurting.

I have had major depressive disorder as well as, generalized anxiety and attention deficit disorder for the past 4 years. I am 24 yrs old. and in the past few years I have tried a whole bunch of anti-depressants. Zoloft, celexa, lexapro, buspar. None of which really seemed to help me. About 5 months ago my psych decided to try something else. Cymbalta. I have had great results with decreasing my anxiety from taking 40mg a day, but still not much turnaround with the depression. Recently, I have changed doctors and have been diagnosed with bipolar II disorder to be the cause of my culmination of symptoms and why the standard anti-depressants have not worked for me. About a month ago I added seroquel to the Cymbalta and Adderall I take. I have slowly worked up to 300mg/day. During this time I have had increasingly painful aches in my upper body. My neck is stiff and sore. My joints all crackle. My wrists are in a great deal of pain. And the worst is the shooting pains I get through out the day in my forearms, which turns into a chronic numbness, predominately on my right side. Ive been told it could be attributed to carpal tunnel, Ulnar nerve entrapment in the elbow, pinched nerves in my neck, or a slipped disc in my back. Or a combination of them.

I've discussed with my pysch, but not sure about these effects? ... and Ive seen my family doctor twice who isn't too concerned with this because "I'm too young" for all of this. Ive started physical therapy in the past week to reduce the pain, they are treating for neck immobility. But this has not really changed the situation. And as the day wears on through use of my arms typing and working it gets to be unbearable. So the next step is a nerve conduction study, and I will be zapped to more accurately pin point the source.

So Im wondering if anyone has had these symptoms as well?

Is it possible that while on the cymbalta which is not only prescribed for depression but also :
- used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes)
- prescribed for fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep).
- and used to treat ongoing bone or muscle pain such as lower back pain or osteoarthritis (joint pain or stiffness that may worsen over time).

that I have been involved in improper posture at my computer for my online class and/or while standing at the work bench @ my job .. and these movements have damaged my body in some way, but was being masked by the cymbalta alone.

Has the seroquel opened up the lines of communication to my pain receptors?

Or is the seroquel in fact causing this pain, tingling, and numbness??

Please lend me your opinion, and quick bc this has become extremely awful and Im so sensitive at times I can't work.
Any advice on this would be greatly appreciated!!

Thanks in advance.
9 Responses
585414 tn?1288944902
  Seroquel can cause movement disorders both temporary and permanent. The temporary movement disorders are common and can be treated with a side effect pill. You could ask your psychiatrist about that. However what you are describing sounds more complex as to what is haappening and you could try posting in the neurology forum. If they are not able to determine the cause it might be worthwhile to see a neurologist as well.
Avatar universal
Hello I take Seroquel XR and needed a side effect drug as I was getting sudden movements, twitches and tensing calves, my pdoc said that out of all the anti psychotics that Seroquel was one of the least likely to cause these side effects but I still got them. I have noticed when my dose has been lowered or when I forget to take it I feel a generalised ache all over my body. I'm not sure if this is tiredness though because the Seroquel makes me sleep so well that without it I would be tired and achey? It feels like the kind of ache you get when you have flu.
Avatar universal
Hi  There.   I have a somewhat similar dilemna.  I was on low doses of Cymbalta with Lithium and Seroquel for several years.  Last fall I went off the Cymbalta, and lo, I began to get neck pain, back pain, all of my 'old friends'.  What is more serious, I did acquire (or have 'unmasked') a mild case of carpal tunnel, as well as pain in my fingertips.   Lithium is usually regarded as the main culprit in the case of peripheral neuropathic pain, and so I am slowly going off of it.  But strong psychiatric drugs in general are suspect, so I gather from reading various lists of causes here (on the web).     You could ask your Dr if you could try an anticonvulsant instead of Seroquel.  Many of those  (trileptal, gabepentin, and others) are prescribed for pain as well as for bipolar.  That is likely the direction I am going to go.   I do not want to remain on Seroquel.   Good luck.
I'm on all that u are on plus tramadol and Gabapentin .still live with chronic pain.really nothing works...it will in the beginning  then ur body gets used to it and it stops.but the meds do more damage  to ur body then anything. Horrible.....
Avatar universal
i to have the same .i got all symptoms you have said i t o though it was my computer work .this has defently been along going process i so cripple im getting a nerve conduction test as well. Iv been to ER so m a ny times bills .ER doctor thinks its seraquil. i take ot to sleep for maybe 5 To 10 YE A RS YOU ARE DESCRIBING. THE SAME SYMPTOMS. I HAVE ITS HARD I HOPE IT HASNT DO LONG TERM DAMAGE ITS LIKE I WAS HAVING A STOKE SYMPTOMS ITS WEIRD STUFF
Finally I quit taking seroquel and feel a tiny bit better. I have been wondering if the seroquel did brain/nerve damage. I cannot break out of constant pain.
Avatar universal
I had taken Cymbalta for 1.5 years and after taking it for a few months, I started having widespread joint pain. The joint pain has gotten worse and is becoming debilitating. Cymbalta has a side affect of joint pain in the literature but the joint pain seems to be permanent! I have not taken Cymbalta in a couple years but the joint pain has remained. I have had blood tests and my doctor says the tests show it is not arthritis.

Stop this drug as soon as you can per your doctors instructions as withdrawal of this drug is also horible! And stop as SOON AS POSSIBLE because from my experience and from what I have read, the joint pain is real and it is PERMANENT!!!!
Avatar universal
First off, A doctor who says you are too young to worry about it, doesn't know what  he is talking about.
since this happened (the pain) since you started seroquel I would get off of it and see if it  goes away. I had pain from taking wellbutrin, quit it and I am fine now.
Then after a while you can try another med. It takes a long time to get the right meds.  i am afraid to try something new b/c changing meds is a nightmare for me. and my husband. I don't think there will be permanent damage.  It might be from another cause.  I recently got carpal tunnel and the osteopathic doctor gave me a wrist brace to wear when I sleep.It stopped the pins and needles and pain in my hand and arm.
Avatar universal
I was 90 mg of Cymbalta and 300 mg of Seroquel daily for 5 years and it had gotten to the point where my legs would just give out and I would fall and I was in pain continuously...so I went off all the medications and the falling and weakness in my legs eventually stopped but I am still in terrible pain...I'm wondering if the combination has cause some form of nerve damage
17719797 tn?1459444127
I have been on Seroquel 600mg and Effexor 300mg. I too am having nerve problems with my ulner nerve, numb, tingling along the inside of my left arm along with the pinky, ring finger and side of my palm. In addition to that, my inside left calf, ball of my foot and big toe are the same. The big problem is that I have an undiagnosed eye pain that is preventing me keeping my eyes open for too long at a time. I hope you find a solution to your problems. Many of the psyciatric meds can cause such random problems, that most Drs just don't know what to do. Let us know what you discover.....Gregg
Wondering about this. Stopped seroquel about 6 months ago but still hurt horribly.
Avatar universal
Ur on uppers & downers how could anyone not expect body pain. I have Hashimoto's hypothyroidism caused by celiacs disease and I use marijuana for my chronic muscle/joint pain. I am 24 years old. I was also addicted to benzos for 2 years. I wish I could find somthing to help besides this, but I've tried everything under the sun. Mary Jane is the best medicine you can have. Man up, come off the pills, be dope sick. No way around it only through it. Make the choice to live a non dependent life at least to ******** meds your Phyc doctor doesn't give a **** about putting you on. Adderol is meth. U might as well be smoking Heroin instead of seroquil cymbalta. Straight up
Have an Answer?
Top Mood Disorders Answerers
Avatar universal
Arlington, VA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
15 signs that it’s more than just the blues
Discover the common symptoms of and treatment options for depression.
We've got five strategies to foster happiness in your everyday life.
Don’t let the winter chill send your smile into deep hibernation. Try these 10 mood-boosting tips to get your happy back
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.