Positive lupus anticoagulant per se cannot make you feel tired. However, since it increases platelet aggregation and thrombus formation, it can narrow down arteries. It can also initiate inflammation of blood vessels. These two processes can make you feel tired. However, other causes like diabetes, hypothyroidism, etc should also be investigated as the cause. Also cause of persistent anemia should be looked into. Anemia can be due to low iron, kidney diseases, cancers (leukemias, Hodgkin's lymphoma's, myeloma, and other blood cancers), aplastic anemia and myelodysplastic syndromes (bone marrow disorders), cirrhosis of liver, lead poisoning, and in vitamin deficiency. Low hemoglobin can also be due to increased destruction of blood or its components as seen in spleen disorders, sickle cell anemia, thalssemia etc. It can also be due to increased blood loss as seen in bleeding in your gastrointestinal tract, either due to esophageal varices, polyps, gastric bypass site, hemorrhoids or an ulcer. In females it can be due to very heavy periods.
You need to consult a hematologist. Also since the INR levels cannot be maintained possibility of IBS, Crohn’s, celiac etc should be looked into if you suffer from acidity and bowel problems.
Also, since you have joint pains etc, lupus, rheumatoid arthritis, avascular necrosis of bone at the joints etc should be looked into. Please discuss with your doctor. Take care!
The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you. The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.
I have lupus anticoagulant since 2005. It is NOT really lupus, it just means your blood clot more than normal. Taking coumadin and having your INR checked by a Hematologist is a must ..They understand the clotting disorder and know exactly how to keep your INR on the right track. Learn what you can and cannot eat. I've lived with this since 2005 and never had any serious problems ...You will be fine!!