ER/PR positivity is better than ER/PR negativity, because presence of these receptors renders the patient sensitive to hormonal manipulation by drugs like tamoxifen, Anastrazole, and Letrozole.
The presence of HER2/Neu positivity means that the patient expresses high levels of a receptor belonging to the EGFR family. This worsens the prognosis.
SOme more information is available here: http://www.breastcancer.org/treatment/hormonal/what_is_it/hormone_role.jsp?gclid=CP2pxaXegJICFQUZewodzzhX4A
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