Dear Jessalynne: There are some chemotherapy drugs for which a lifetime maximum dose applies. Neither cytoxan nor taxotere fall into that category. The limits of use of these drugs relate more to toxicity, ability to tolerate, and efficacy (where applicable). Hemorrhagic cystitis is a well documented but not terribly common side effect of cytoxan. For this reason, patients are encouraged to remain well hydrated to keep the bladder flushed out during treatment. In terms of what drugs should be used in any given situation, this would be up to the oncologist. Certainly, there is more than one acceptable regimen. If you are concerned, you could consider a second opinion (preferably with an oncologist who specializes in breast cancer) so that you can compare plans. It may help you with your decision about how to proceed.