I've gone through a very traumatic experience, both psychologically and psysically.
I was diagnosed with breast cancer (in 2004). I had a radical mastectomy, followed by 25 courses of radiotherapy and a series of four months of FEC chemotherapy. The stage : T2N1M0. The cancer cells have been found in two lymph nodes.
Since March 2005, I follow the treatment with Tamoxifen (it was given for five years).
The IHC tests are : ER -positive / PGR - positive / CerbB2 - positive (+).
I'm worried about the positivity of CerbB2 (+), knowing that has a bad prognosis in disease evolution (compares with the pacients CerbB2 - negative)
Till now, my medical tests are okay, CA15-3 betwwen 9 - 13 U/mL.
My question is that you think the treatment is the right one, or you think is better to replace Tamoxifen with someting else? (Arimidex,etc..)
Many thanks in advance for your reply and all the best!
Dear Denisa: Tamoxifen is a hormone therapy that blocks estrogen to breast tissue. It is the hormone that is recommended for women with ER/PR positive breast cancer who are premenopausal or postmenopausal. Arimidex (or other aromatase inhibitors) is another class of hormone therapy that also blocks estrogen to breast tissue but these drugs are only offered to women who are postmenopausal. Both tamoxifen and armidex only address the ER/PR status and do not have any impact on CerbB2. There are medications available to address CerbB2 positivity in the US (trastuzumab (Herceptin) and Lapatinib (Tykerb). Whether or not these would be under consideration would depend upon your situation and your oncologist. You should discuss your questions with your oncologist who can discuss this within the context of your situation.
Many thanks for your quick reply and kindness.
I forgot to tell you that I had also a hysterectomy after the mastectomy (at 40 yrs old). Now I'm 44 yrs old and I can say I'm a postmenopausal woman. It's now 4 years since I take Tamoxifen (I informed you that it was given for 5 years).
Do you think is better to switch with Arimidex for 1 year? I've heard thet Arimidex is slightly better than Tamoxifen.
Sorry to be a trouble with my questions, but I think you understand me...
Copyright 1994-2018MedHelp.All rights reserved. MedHelp is a division of Vitals Consumer Services, LLC.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.