Dear mjay, I did some checking regarding dosing of medroxyprogesterone for treatment of hot flashes. After some amount of investigation the information was that 10mg pill daily was the recommended dose. The idea being to use the lowest amount of the medication to take care of the symptom. You should know that the resources quoting the studies of its use for treatment of hot flashes are from 1980 and 1981 journals. There could be more up to date findings but I did not come across any.
Current indications for the use of Medroxyprogesterone are secondary amenorrhea, abnormal uterine bleeding, as treatment of uterine cancer or kidney cancer when used in much higher doses.