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I was diagnosed with stage 1 breast cancer in June 2010.  I had chemotherapy and radiotherapy and finished my treatment in June 2011.  I was advised by my Oncologist to start taking Tamoxifen after my radiotherapy had finished.  I have been taking Tamoxifen for 3 months, but decided to come off it because of the side effects, the main side effect being depression.  I was crying most days and very argumentative and compulsive about certain issues.

I have informed my Oncologist and breast care nurse of my decision.  My Oncologist said that it was the only hormone drug I could take because I was pre-menopausal.  They are going to do a blood test to see how far into the menopause I am.

The breast care nurse also said that my estrogen level was 170/300 and advised that I could have my ovaries removed as another option and then go on another hormone therapy with hopefully without the side effects of Tamoxifen.

Should I have my ovaries removed and not take a tablet, would this be sufficient enough to ensure the cancer doesn't return.

Also going through a menopause having my ovaries removed could make me have mood swings also.

This discussion is related to ovary removal and tamoxifen or arimidex.
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739091 tn?1300669627
The age old question... to tamoxifen or not to tamoxifen.

Sorry you're in this situation! I know, I've been there myself. Something for you to consider is the benefit of taking tamoxifen for as long as you can.

Tamoxifen tells your body that it's in menopause. Depression is a side effect of menopause. There is a pill you can take for depression that will keep that in check while allowing the tamoxifen to do what it does best which is to block any estrogen produced by your body. Ovaries, body fat and adrenal glands all produce estrogen. As long as you're on tamoxifen, none of the estrogen will feed your estrogen fed cancer. How old are you? I got my cancer when I was pre-menopausal at 52 and even after chemo, radiation and tamoxifen I didn't go into menopause for another year and a half (verified by blood testing).

I guess my point in all of this is, if you're having issues with depression while in a tamoxifen induced menopause, then it's very likely that you will have the same issue when you are in full menopause. So taking something like lexapro can control the crying and depression and anxiety etc and still allow you to stay on the drug that is doing the most good for as long as you can. If you get your ovaries removed, you will still end up on an estrogen blocker in the form of an AI. They tend to have similar side effects, I know because I went there too. So, if you have the surgery, you will be thrown into instant surgical menopause with all that it entails and you will still be taking that little pill along with something for depression. It's a toss up. If you are under 40 do NOT have your ovaries removed. If you have a BRCA mutation, you may want to speak with a genetic counselor to get the best info for your exact situation.

Best wishes!
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