My sister (47) was diagnosed with breast cancer (T3, ER+, PR+, HER2-) 4 years ago. She had radiotherapy, followed by mastectomy+radiotherapy and chemo with anthracycline, followed by tamoxifen.
October 2007 she was diagnosed with brain metastases (not operable). She was treated with radiotherapy and temodar, which initially had some effect, but then in July 2007 the metastases progressed and her left leg and arm were paralyzed.
She is currently taking CCNU (she had her second treatment a few days ago) and several natural supplements, including Boswellia Serrata (4,200 mg/day; CoQ10, melatonin, bromelain, low fat cottage cheese and flax oil and seeds) and she is on a low fat diet. However, no much improvement has been noticed.
I would appreciate any advice/suggestion about treatments of brain metastases that could be relevant to my sister's case. What do you think about using xeloda, faslodex, letrosole (femara), or insulin potentiation therapy in the treatment of brain metastases from breast cancer?
It seems that a major issue is whether the drug crosses the blood brain barrier. However, it is known that in case of brain tumor/metastases the integrity of the blood brain barrier is compromised?
Dear winter09: Brain metastasis can be a difficult problem to treat. Without evaluation, it is impossible for us to speculate on the specifics of your sister's situation. You might consider an opinion from a brain tumor specialist at a large center if this is a possibility.
Copyright 1994-2018MedHelp.All rights reserved. MedHelp is a division of Vitals Consumer Services, LLC.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.