p450 tested

[jmlane]

Hi Everyone,  has anyone had their p450 2D6 checked for Tamoxifen metabolism??  I am an intermediate metabolizer and can't find any info on how our dosage is changed.  Would appreciate any thoughts on this.

Thanks
jan

[PaulMD]

Hi there.

I'm not sure if you will be able to find the dosage modifications for this readily, since there may be no real concensus or standard recommendations for such.  Testing for the different isotypes of the p450 enzymes is really not standard practice and different hospitals may have different protocols for this.

I suggest that you ask the hospital or the doctor who requested the test since they may have their own protocol regarding tamoxifen dosage adjustment in accordance with p450 levels.

Regards.

[jmlane]

Thank you for your thoughts.  I took the initiative to be tested for 2D6 on my own as I suspected something wasn't right.  I also think it's an excellent idea and could possibly explain why Tamoxifen fails 30%???
of women.  Kinda wanted to know a head of time.

I can not find one example of re-dosing Tamoxifen based on p450 values.
I even wrote the Mayo Clinic in "ask a specialist".  No answer. And they promote the testing!!

Thank you for taking the time to address this.
jan