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774271 tn?1235408091

Can someone please help me decipher my "cold knife cone biopsy of the cervix"path report?

My regular GYN has done a couple of in office biopsies and now a cold knife cone biopsy. The end result was him telling be that the deepest point removed tested with micro invasive cervical cancer and he is sending me to a gyn oncologist. I have been trying to decipher the terms listed but I still need some help. Like... When they say Histologic Grade: Grade 2 (Moderately Differentiated), what does that mean? Based on what's given in the report can anyone give me a better idea as to the severity of my carcinoma? The report reads as follows...
A. "Cone biopsy of the cervix"
Histologic Type: Squamous Cell Carcinoma, Nonkerantizing
Histologic Grade: Grade 2 (Moderately Differentiated)
Stromal Invasion: Depth is 2.5 mm, Horizontal Extension is 1.5 mm
Endocervical Margin: Involved by Invasive Carcinoma
Ectocervical Margin: Uninvolved by Invasive Carcinoma
Deep Margin: Uninvolved by Invasive Carcinoma
Lymphovascular Invasion: Absent

B. "Endocervical Curettings"
Benign Endometrium of lower uterine segment and blood
Rare benign Endocervical Glands
Negative for Malignancy

Comment:
There is diffuse koilocytosis and parakeratosis. Thers is focal carcinoma in situ and invasive of moderately differentiated carcinoma into the submucosa. There is marked chronic inflamation and squamous metaplasia. Koilocytosis (with CIN 1) extends to the ectocervical margin.However, invasive carcinoma involves the endocervical margin. Additional deeper levels showed similar changes.

Gross Description:
A. "Cone biopsy of cervix" -An unoriented cervical cone biopsy is 2.7 x 2.3 x 1.5 cm. The specimen is inked black and serially sectioned.
1-4 - AS - M
B. "Endocervical curettings" -Pieces of pale tan tissue mixed with mucus are 2 cc in aggregate.
1,2 - AS - M
2 Responses
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774271 tn?1235408091
Thanks for the response. No clear margins. I just saw the oncologist on the 24th and from what he said which concurred with my normal gyn, all of the margins are compromised. I specifically asked for his opinion in staging and he said he won't give me staging till he has a second cold knife biopsy report in hand. So on Wednesday the 4th I already have the 2nd cone scheduled with the new oncologist.This cone being deeper and larger because he must exceed the previous margins. He's pretty quick with getting things going being this is scheduled within 1 week of meeting him. Once we get the results in he will give me staging and also let me know if it's possibly safe enough to have 1 more child while being closely monitored. He said if he had it his way he'd be scheduling a hysterectomy rather than a cone biopsy but has to take into consideration that I desire another child. All I can do is hope.
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Avatar universal
Grade 2 refers to the aggressiveness of your cancer cells. The higher the number the more aggressive the cancer is considered to be. 2 isn't bad. That is what mine was. It means that the cells are somewhat different than normal cells. Did he say that he got clear margins?  I'm just guessing that maybe he didn't since he referred you to a gyno/onco which is the BEST thing he could've done for you, they are the experts in this area and will give you the best possible care. Did he give you an idea as to what stage this might be? They usually can't say for sure until after further investigation.
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