My regular GYN has done a couple of in office biopsies and now a cold knife cone biopsy. The end result was him telling be that the deepest point removed tested with micro invasive cervical cancer and he is sending me to a gyn oncologist. I have been trying to decipher the terms listed but I still need some help. Like... When they say Histologic Grade: Grade 2 (Moderately Differentiated), what does that mean? Based on what's given in the report can anyone give me a better idea as to the severity of my carcinoma? The report reads as follows...
A. "Cone biopsy of the cervix"
Histologic Type: Squamous Cell Carcinoma, Nonkerantizing
Histologic Grade: Grade 2 (Moderately Differentiated)
Stromal Invasion: Depth is 2.5 mm, Horizontal Extension is 1.5 mm
Endocervical Margin: Involved by Invasive Carcinoma
Ectocervical Margin: Uninvolved by Invasive Carcinoma
Deep Margin: Uninvolved by Invasive Carcinoma
Lymphovascular Invasion: Absent
B. "Endocervical Curettings"
Benign Endometrium of lower uterine segment and blood
Rare benign Endocervical Glands
Negative for Malignancy
Comment:
There is diffuse koilocytosis and parakeratosis. Thers is focal carcinoma in situ and invasive of moderately differentiated carcinoma into the submucosa. There is marked chronic inflamation and squamous metaplasia. Koilocytosis (with CIN 1) extends to the ectocervical margin.However, invasive carcinoma involves the endocervical margin. Additional deeper levels showed similar changes.
Gross Description:
A. "Cone biopsy of cervix" -An unoriented cervical cone biopsy is 2.7 x 2.3 x 1.5 cm. The specimen is inked black and serially sectioned.
1-4 - AS - M
B. "Endocervical curettings" -Pieces of pale tan tissue mixed with mucus are 2 cc in aggregate.
1,2 - AS - M