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Liver Cancer

Is it possible to develop Liver Cancer with only having minimal stage 1 damage?
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It is possible, but is extremely unlikely. In the cases involving almost normal livers, any liver cancer will almost always be metastatic, not primary. The best liver tumor imaging technology will be MRI with dynamic contrast enhancement. And primary liver cancer, HCC, will likely show an elevation of blood serum AFP - Interhepatic Cholangiocarcinoma (really bile duct cancer), ICC, will likely show an elevation of blood serum CA19-9 and CEA.
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