Hi Just wanted to ask if the CA 125 goes up before it comes down in doxil. My mums CA went from 1200 to 1800 after first dose of doxil. I would also like to ask why recurrence has a lower response to chemo. If they are the same type of cells why is the chemo response negligible or minor. Why is it such poor prognosis on recurrence. Does this occur with all types of cancer and does it tend to be more with advanced cancers. Is chemo useful in relapse and progression compared to stable disease. Can there be remission after recurrence treatment or not. All this is confusing so if you could maybe make it a bit easier to understand. Many thanks
Occasional "flares" are seen, when tumor markers transiently rise when a new therapy is begun.
Recurrence is known to be less responsive than the primary tumor in most human malignancies. The reason is that the initial chemo kills the sensitive cells, and the remaining ones are more hardy and resistant. These tough cells then begin proliferating and cause recurrance. When this second tumor is detected, it is already populated by resistant cells which respond less well to chemotherapy.
All the best, and God Bless!
Many thanks for yr answer. Very clear and now my way of thinking has changed regarding my mums cancer. With the rise of CA being dramatic does that signify the cancer recurring aggressively. Also does second surgery not help in removing the chemo resistant cells. Her response now has been her CA dropped from 1800 approx. to 1650. I know its not a big rate of drop but surely some response is better than none. Would there come a point when the marker rises. Is it from this that a prognosis is made. With yr experience what would you give approx as a prognosis on my mums cancer knowing she had response to chemo for 4 mths before recurrence but also had 4 mth chemo holiday. In those 4 mths her CA went from 112 to 1200.Any indication or knowledge you impart would be so appreciated. With every info we gain more insight into what we are dealing with. Many thanks again.
Could you let me know the chemo regimen your mother had the first time around, the number of cycles, and the dates when it was given?
This would give me a clearer idea of her clinical history.
Copyright 1994-2018MedHelp.All rights reserved. MedHelp is a division of Vitals Consumer Services, LLC.
The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We offer this Site AS IS and without any warranties. By using this Site you agree to the following Terms and Conditions. If you think you may have a medical emergency, call your physician or 911 immediately.