Urticaria, or hives, is truly not one disease, but a reaction pattern of the skin.
In most of the cases of chronic urticaria, the underlying pathology is idiopathic i.e it is not linked to any cause. Idiopathic urticaria and angioedema can even be accompanied by symptoms and signs of anaphylaxis in a syndrome called idiopathic anaphylaxis.
It is essential to rule out the presence of serious illnesses of which recurring hives can be a symptom. Examples are hepatitis, hyperthyroidism, lymphomas, collagen vascular diseases, and cancers of the rectum, kidneys and gastrointestinal tract. Chronic infections such as chronic sinusitis can be associated with urticaria.
Causes of urticaria include Drugs and Chemicals, contactants, certain foods, infections and systemic diseases.
Have these systemic diseases being ruled out in your case?
Treatment is by oral antihistamines. The most potent antihistamine, however, is probably the anti-depressant doxepin. Although adverse effects (including sedation, increased appetite, and possible cardiac effects) often limit its use, doxepin is perhaps the most effective of all the antihistamines for urticaria and angioedema.
Unfortunately, however, a few patients respond only to systemic steroids. In this case the best mode of action is to give a short burst with a moderate dosage (e.g., prednisolone 1 mg/kg/day), and then try to taper the dose of steroid as antihistamines are introduced.
Lastly,immunotherapy can be tried.
Pls consult an immunologist for the exact diagnosis and treatment as an allergy specialist/immunologist can only handle such kinds of cases.
Take a look at the thread by bwb ,top thread,dated July 25th on on going, it has a lot of information that I have found very helpful as I like you suffer from this .there are a lot of ideas for things that help.
Its now July 2015 my hives went away but reoccured a few weeks ago also Dermagraphism after taking and stopping Bactrim I also had many other nasty symptoms, I looked it up and this is one bad drug ..so now I am back where I was in 2008 .