Remember that bipolar 2 isn't bipolar at all, it's just a form of depression. Don't know about all this borderline stuff. Most of these designations are to allow medications to be used, but only true bipolar is an incurable psychotic ailment. So there are lots of drugs for this. Seroquel probably isn't one of the first I'd try, at least not by itself -- it was notoriously marketed for unapproved purposes and was sanctioned for it. As for natural medicine, that's very complicated in the treatment of mental illness. It requires a lot of different remedies, a lot of experimentation, changes in diet, exercise, meditation, etc. A good overview to get you started is Natural Highs by Hyla Cass, a psychiatrist at UCLA who uses natural medicine in her practice. But each individual is different, so if you want natural methods I'd see a psychiatrist who practices integrated medicine or you could try a naturopath. As for different medications, there's the whole panoply of antidepressants and atypical antipsychotics out there.