I've had these symptoms severely now for about 4 years. It started with muscle weakness, fatigue, muscle pain, buzzing or tingling sensation in my feet, legs, arms and hands, tremor and uncoordination. I was a retail manager and working very long difficult hours. It got so bad I couldn't do my job. I went to my doctor. I presented with a high ANA of 1:640 with a speckled pattern but SED rate was normal. I also had hyper reflex action, heart arhythmia and granuloma annulares rashes on my inner thigh and arm pit. Over the past 4 years my symptoms seem to go in spurts, sometimes pain is prevelant, sometimes the buzzing and weakness. I have developed severe neuropathic burning and pain, muscle stiffness and muscle cramps mostly in my legs and feet. I have had bloodwork several times and ANA and SED remain the same. My doctors still have not come to a diagnosis.