I went to my doctor the other day to discuss my medication. I was on Wellbutrin but was very aggitated on it, constipation, cried easily, one day I was happy the next I was depressed. She put me on Effexor XR. I have been on it two days and I feel very groggy all day. I feel that I am not sleeping well either. Will this go away after I have been on this a couple weeks? I was also conerned about weight gain, I do not want to gain weight on this, I've read that some people have gained weight on Effexor. I used to be on Prozac too but never gained weight on that or Wellbutrin. The reason I didn't stay on Prozac is because of the sexual side effects and felt it wasn't helping me much either. I worry a lot and didn't feel that helped either. Does Effexor help with anxiety (worrying)? I was very constipated on Wellbutrin. Can this happen with Effexor too? I am going for blood tests to check my thyroid, liver, kidneys, blood in stool. Is Effexor a good anti-depressant. My doctor said most of her patients did well on it, I hope I do too. Thank you for listening and for anyone's advice.