I suffered a "nervous breakdown" in 1975. I experienced a high state of anxiety, agoraphobia, depression, panic attacks, and tremor in my dominant hand/wrist. Due to the tremor, I was unable to write or eat in social situations. Being a part-time musician, my first acute panic attack was experienced at the beginning of a performance and was accompanied by (or triggered by?) the tremor. I was teaching, selling insurance, going to graduate school, starting a family - under much stress. I had to quit my job, but was never hospitalized, and eventually went back to teaching and music, although very difficult most of the time. My only medication, prescribed by my GP, was Valium, and I have taken 2.5 to 20 mg/day ever since - usually about 5 mg/day now since retired. In 1987, my depression became severe -no sleep, suicidal thoughts, etc. and I consulted a psychiatrist and have been under his care ever since. I underwent individual psychotherapy, goup therapy, and prescribed 225 mg of Tofranil at night, 120 mg of Inderal in the morning, and Valium "as needed". I was able to function well at work, moving into administrative positions and able to perform comfortably enough to enjoy playing music more. Since retiring, I have been interested in possible alternatives to the Inderal because of side effects - becoming totally exhausted at times (several times a month), sexual side effects, etc. Although I discussed trying 50 mg of Topral XL with my Psychiatrist and cardiologist (no major heart problem, but I do take 5 mg of Norvasc and 10 mg of Lipitor at night) and they both suggested giving it a try since "any beta blocker should work with the tremor". I am concerned that, after taking the Topral XL for 4 or 5 days that I am experienced more exagerrated tremors (also developed tremor in my neck 8 or 9 years ago), and have wondered if the 50 mg of Topral is equivalent in strength to the 120 mg of Inderal. I have asked both doctors and a pharmacist, and did not feel I received an explicit answer. Could the time-release factor be involved? Any information concerning the use of the Topral XL verses Inderal will be greatly appreciated.