My husband was diagnosed with depression last year. He started taking Lexapro and it made a huge difference in his mood and anger levels. Unfortunately, the Lexapro made him loose his appetite and become very nauseous . He also felt like it was loosing its potency after a few months. His doctor tried to raise his dosage to combat the diminishing effects, but his stomach couldn't handle that. He was switched over to Prozac (after a few weeks of titration). At first, when he wasn't all the way off of the Lexapro, the combination of the two drugs made him feel euphoric, but also made him more up tight and quick to anger. Once he was only on the Prozac he became out of control. He would loose his temper and be thrown into a rage that he could not calm down from. He was very worried about what was happening to him so he called his doctor and was told to go off of the Prozac immediately(with no titration). He took just 5mg of Lexapro a day while he was waiting to see his doctor again. Now he is starting on Zoloft, and it seems to have similar symptoms of making him feel uptight and anxious. His doctor questioned him thoroughly about his side effects to make sure that he is not bipolar and being thrown into a manic fit by the SSRIs. I don't know what would be the best course of action for him from here. He needs something to help him with his mood, but I am worried that he will tire of trying so many different meds. Please help. Thank you.