Lamictal has not been approved for use to treat Major Depression however some case reports had been published recently for its efficacy to treat bipolar disorder symptoms - mania and depression. There has not been evidence to support its use in Major Depressive Disorder. MAOI (monoamino oxidase inhibitors), on the other hand are very well researched and very effective.
The information provided by the makers of Lamictal reveals that the there are no factors identified that are known to predict the risk of occurrence or the severity of rash associations with Lamictal. Although benign rashes also occur with Lamictal, it is not possible to predict which rashes will prove to be life-threatening.
You may want to review other information available to you with your physician regarding the use of Lamictal and MAOI to treat your depression.
HFHS MD - RG