My dad is diagnosed with Bipolar Disorder. He has been taking Effexor and Depakote which has successfully brought him out of a depressed state. His wife asked his psychiatrist to find a substitute for the Depakote due to significant weight gain. The doctor prescribed Tegretol instead. Then my dad quit taking his Effexor (I'm not sure why) and his depression symptoms suddenly returned. He is also very anxious, will not talk to his children on the phone, does not want to do anything but lay around, and is very shaky. This has been since October (it is now almost March!). He has since been prescribed a slew of medications which proved ineffective. Recently, about two weeks ago, his psychiatrist decided to re-prescribe Effexor XR 150 mg QAM, Depakote 500 mg BID, and added on Prozac 120 mg QAM, and 20 mg at night since the Depakote and Effexor has brought him out of depression in the past and try him on a weight management program instead. About a week later, he was omitted in the hospital for falling down and acting confused. The doctors at the hospital diagnosed him with postural or orthostatic hypotension and prescribed Mitradine, Flurocortisone, and Tenormin and discontinued Flomax (which he had also been taking for quite some time as prescribed by his PCP to help him urinate), saying that the medication is what caused his hypotension. Also at his next psychiatrist appointment just days later, his psychiatrist discontinued the Effexor and Depakote and changed his Prozac dose to 20 mg three times daily, and added Valium 5 mg prn. He is not any better since returning from the hospital after four days other than his blood pressure. Now since doing some research on the internet, I am wondering if he is experiencing withdrawal symptoms from the sudden onset and discontinuation of Effexor and Depakote, and maybe even serotonin syndrome from taking the Prozac with the Depakote? Please advise. Any information from another psychiatric professional would be extremely helpful!