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I have had panic disorder and agoraphobia for approx. 20 years, in this time I have been on many different meds (zoloft,paxil,surmontil,marplan,nardil,buspar,xanax,klonopin etc) and I am now on lexapro and klonopin. I still suffer severe panic attacks and agoraphobia, which now has affected my job. My job location has been changed due to forced rearrangement and I have not been able to get myself there without severe attacks. I am at a loss, I have been through C.B.T, relaxation,hynotherapy,deep breathing exercise,group therapy and a few other "therapies". When I get an attack it usually brings on severe chest pain, tingling in the arms and hands, confusion, typical fight or flight responses and a disassociated feeling as if I am not attached to my body. I have had CAT and MRI scans. A particular CT scan when I was 19 (I am now 37)comes to mind. The scan showed an "abnormally" large pineal gland which at the time the New England Deconess Hospital didn't seem to know much about (1984) so they sent me to the Mass General Hosp. where they did a MRI told me that the pineal gland was not tumorous but overly calcified and that it isn't dangerous. They also gave me a anticonvulsant medication I believe was Tranzene? The medication caused severe headaches and I was taken off after approx. 3 weeks.
I guess I just want to know if any correlation studies between the Pineal gland and Panic have been done and if so the results. Also I don't know where to turn as far as medications. beta-blockers? Can panic disorder cause back pain through the ribs whereas when you take a deep breathe your back locks up.
I know I am asking alot but I am convinced that there is alot about this disease that is not known. I have read over 50 books on the subject and the so called cures and have found none that actually work. I now may lose my job because of this and I have a wife and 2 children to support. If you have any ideas that may help please let me know because I am at my wits end!! Thank You in advance Michael Rando, Everett, MA.
ps: you can post my name
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242532 tn?1269553979
I am inserting a review article for your information.  there is noting directly about the pineal gland.  If the whole article doesn't come through here, go to psychologytoday.com and look at panic in their archives and search for this article.
anic, 1

Panic attacks. The anxiety and panic are real. And terrifying. But they've been a mystery to researchers and clinicians who've been trying for years to pinpoint the cause. Now, the psychiatrist who put the disorder on the map says he's found the culprit and it's strictly biological. It's not a matter of past experience. It's a case of faulty wiring--a defect in the way our brains warn against suffocation.

Along with assorted other alarms, the human brain has a warning system that fires whenever the amount of carbon dioxide in the blood becomes too high--a sure sign of oxygen deprivation. In some people, the system is overly sensitive and fires spontaneously at the slightest increase in blood CO2, says Donald Klein, M.D., professor of psychiatry at Columbia University.

The false alarm then sets off a cascade of events that culminate in panic attack. just before the attack, the victim is overwhelmed by feelings of suffocation and tries to compensate by breathing deeply. But it's too late, and heavy breathing can't alleviate the feeling of suffocation.

"The brain then says 'let's get out of here,"' observes Klein. "People having panic attacks often run to the window and throw it open. They are trying to get some air in."

Proof that a suffocation monitor exists, he says, lies in infants who are born without one, those with the defect known as Ondine's curse (sleep-induced apnea). Suffocation is particularly adversive to the human brain, and most infants cry instinctively whenever their noses are held--a minor panic reaction. But these children calmly suffocate.

Klein dismisses intense fear as a cause of panic. "The outstanding thing about panic is that it is not motivated by fear," he says. "That's just a mistake." He points to the many people who get panic attacks during sleep or deep relaxation-states where oxygen deprivation is the norm but little anxiety exists. Besides, if fear were behind panic, sufferers should show increased levels of adrenalin, and they don't.

Panic, 2

Sure, says a team of Pittsburgh and New York psychiatrists, some biological predisposition does exist. But panic attacks don't happen in the absence of certain kinds of early experience and psychic conflict.

Resurrecting the theories of Sigmund Freud, they insist that both biology and early experience conspire to cause panic. In their neo-Freudian model, innate temperament, psychodynamics, parental behavior, and objective and subjective experience all play a role.

People with the disorder are born with a neurophysiological irritability that shows itself as early fearfulness. As children, they typically fear new or unfamiliar situations. Their parents, perhaps anxious or prone to panic themselves, fail to ease the way they fit with the world and wind up exacerbating the child's fearful nature.

The child feels threatened and suffocated by their parents' behavior but at the same time becomes overly dependent on them. In adolescence, the child becomes very complacent and eager to please, but at the same time resentful of authority.

Now the steep slide towards the first panic attack begins. At some point in early adulthood, something happens, usually involving a powerful other or figure of authority, to make the future sufferer extremely angry or upset. Already predisposed toward fear, they become frightened at their intense negative emotions. Anger leads to a physical response-heavy heartbeat, sweating, anxiety-and this triggers a fight-or-flight reaction in the brain: a panic attack.

The first attack begins a vicious cycle. Fear of another panic attack leads to more psychological vulnerability, which leads to more fear that may result in another panic attack. In some sufferers, the attacks may occur over a brief period of time and then never reappear. But in others, the endless chain of fear and panic may go on for years, virtually destroying their ability to function normally, according to Katherine Shear, M.D., professor of psychiatry at the University of Pittsburgh, and colleagues.

Their bold new theory, reported in the American Journal of Psychiatry (Vol. 150, No. 6), is the outgrowth of interviews with nine patients suffering from panic disorder, published reports of psychological characteristics of panic patients, and data from animal and infant research on temperament. All patients describe themselves as shy and nervous as children, and their parents as suffocating, critical, and demanding. All reported later problems with overdependency and fear of authority. And all described stressful incidents just before the onset of their first panic

Avatar universal
I know of people in an continouous state of anxiety and frequent panic attacks that did not respond to the newer medications. The condition improved when immiparmine or desipramine was used.

Betablockers are still used to prevent attacks with reasonable success.

There is information of research that link the Pineal to the normal daily cicle of the norepinephrine(one of the substances implicated in regulation of affect).
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