I'm a 47 yr. old female with 2 children. I have had depression and anxiety my whole life, with 3 major depressive episodes. I was given Paxil 20mg. 15 years ago and felt happy for the first time ever. Over the years I've had to have my dosage increased to 50mg. About a month ago I started to feel the old symptoms returning again. (not sleeping well, nervous stomach, anxiety, depression.) My doctor increased my Paxil to 60mg. I felt better in about 4 or 5 days, and then I started feeling really bad( nausea, stomach ache, anxiety, depressed) My doctor checked me for a urinary tract infection and indeed I had a whopper of one so she gave me an antibiotic and it went away. I thought that the UTI may have been making me feel bad all along,(I always feel some anxiety when I get ill( so I decreased the Paxil back down to 50 mg. Within a week I was feeling the anxiety and all that again, so I went back up to 60mg of Paxil. It's been about 4 or 5 days and I still have some anxiety and sleeping problems and just feel ill at ease. Do you think I needed to stay on the Paxil all along and how long until it starts to work again? I also take Klonopin for anxiety, but it still doesn't really get rid of that "ill at ease" feeling inside. Any advice would be very much appreciated. As an afterthought about month before all this I had a sinus infection and was given Cipro and had a bad reaction to it. Major anxiety and mood change. I only took the Cipro for 3 or 4 days and then quit and the symptoms went away.