55 yo male - long hx of intermittent depressive episodes since early 20's. Never interferred much w/ occup or marital adjustment. Mostly have used psychotherapy w/ some adjunctive meds on occasion. Past meds have incl zoloft, prozac, buspar, paxil @ relatively low doses for relatively short periods of time (6 mo - 1 year). Currently taking Wellbturin SR 150 mg in AM -- for about past 8 months. Increased energy. But still having trouble "getting out there and enjoying life" the way I would like to. I am considering talking to my MD abt Wellburin + Zoloft combo. I've never taken more than one psychotropic at a time, and am leery abt taking a lot of meds anyway. Zoloft helped 5 years ago bring me out of my only major depressive episode (which lasted circa 4 months and resulted in my taking several months off from work). No hosp. No suicidal ideation.
My Q: Is there literature or clinical/anecdotal evidence suggesting these two might work well in combination?