I was diagnosed with depression and generalized anxiety disorder about 10 years ago. During those 10 years I was prescribed a number of different combinations of medications like Risperdal, Trazadone, Paxil, Trileptal, Klonopin, Geodon, to name a few. Some of those combinations had horrible side effects and never really relieved my anxiety or depression. Now I'm on 112.5mg of Effexor ER, 200mg of Lamictal, 60 mg of Buspar, 1200 mg of Neurontin, 600mg of Seroquel and .5 mg of Xanax ER as needed. I feel better than I ever had in my life, but the only problem I have now is excessive weight gain--about 30 lbs. I am currently 5'7 and 188 lbs. I want to get my weight down to 160 lbs. As a New Year's resolution I have been working out between 30-60 minutes 5 days a week combining cardio and weight training. I have also adjusted my diet by eating more fruits and vegetables and whole grains. I have lost about 5 lbs. in 6 weeks. I feel as if the Seroquel is inhibiting my weight loss. I read that Metformin is now being prescribed to aid in weight loss for people on antidepressants. Has anyone had any success with losing weight while on these antidepressants? Has anyone tried Metformin for weight loss?