Hello I quit Effexor cold Turkey about 3 months ago. I was being treated for Anxiety and PMDD, as well as IBS. Im not one to take pills and although it helped me I got this idea that because I forget to take my effexor sometimes and feel really tired and yucky, I should just stop completley. Well the problem with that was I had all sorts of issues, I gained 19lbs in a month my stomach was so distended I couldn't do up my blouse, indigestion and gas was horrible and my periods were so heavy i was changing my pads every 1/2 hour. I have decided to start taking them again as I know it was helping me. I didn't gain weight like everyone else says they do when I was on them, just after I stopped. I was only on 37.5 mg for 6mnths, my doctor told me I could increase the dosage whn I was PMSing as I felt like it wasn't working, and well thats when I decided to quit taking them. I have read so many terrible things about antidepresents and feel almost imbarrased taking them. You also read all kinds of material on how bad it is and doctors over prescibing them. However I have come to the conclussion I do better on them. What I am concerned about is will they work the same way they did the first time? Is it possible they might not work as well and should I up the dossage to 75mg as oposed to 37.5mg? Im not to worried about the weight gain as I didn't gain any weight when I was on them, my stomach issues, PMDD, and Anxiety went away. Although if I do notice I am starting to gain weight I might stop taking them.