Treatment resistant just means you haven't found a treatment that works yet. I'm confused, though -- you say you're taking Cymbalta while you're still taking Effexor, and have just started tapering off the Effexor? Are you on a therapeutic dose of the Cymbalta or a starter dose? I'm wondering why your doc didn't taper you off the Effexor before starting the Cymbalta, or at least go through a good part of the taper off before doing that so you wouldn't be on two drugs at the same time, especially that work on the same neurotransmitters, so you'd know how well you were doing tapering off the Effexor, and how you were reacting to the Cymbalta? It's possible that part of your reaction is fear, but it's also possible it's being on two drugs at the same time that do the same thing, though in a slightly different way, and suffering side effects of that.