Most people who take too many drugs are depressed and are self-medicating. Obviously, from the behavior you describe, even if your brother wasn't playing around with, I might add, some pretty odd drugs to play around with in some cases, he would need help. Drug rehab is for people who are addicted to them -- if he's not, they probably won't take him. Mental health facilities also don't take many people these days unless they're a current danger to themselves or others, and even then they don't keep them long -- not enough beds. Outpatient psychologist and psychiatrist are probably where he's going to end up anyway. I don't really know how you're going to learn if he's taking so much meth he's addicted to it, but given he's taking weird combos of drugs maybe a drug rehab facility will take him, but if you know the depression is the cause, then that's what needs fixing -- most people get out of drug rehab and just start using again because all the reasons they had for using are still there. So you need to do some homework both on what's available in your area, whether they'd take him or not, for how long, and what's really going on with him because it will go a long way to determine how bad off he is and how much immediate danger he's in. But you can start outpatient any time, assuming he's amenable to it.