I have never written in a forum before, but have been reading these for awhile now, especially since trying to get off Effexor XR. I have been on Effexor XR 225 milligrams for about 6 years after an extremely difficult 6 months at the time resulting in major depression and anxiety with panic attacks. To me, Effexor XR with an occasional alprazolam 0.25 milligrams (Xanax) had been the miracle drugs and saved my life. I take my medication every morning anywhere between 8 and 10 a.m. depending on what time I get up. I have a few of the "common" side effects of Effexor being weight gain (about 20-25 pounds), night sweats, feeling on "cloud 9", brain shocks, tingling, etc. I am also a lot more forgetful than I have been in the past as well as having trouble "finding" my words. In the past few months, I have been experiencing "withdrawal-like symptoms" at around 5 p.m. in the afternoon, even though I took my medication that morning. I also had full blood work recently that showed I had abnormal lab values in my liver function tests, my alkaline phosphatase. It made me a little concerned, so after talking to multiple people (who all hated the fact that I was on Effexor) and 2 of my doctors, I decided maybe I should wean off the medication and try something different - Wellbutrin. I weaned myself off the Effexor over a 2-month period and took my last dose of 37.5 milligrams 5 days ago. I only took the 37.5 milligram dose for about 5 days, and then decided I was good since I was not having the "brain shocks", tingles in my fingers, etc. Over the past 5 days, I have had 3 extreme panic attacks where I almost called an ambulance, I cannot stop crying, and I feel like the only thing that will make me feel better is to take a sledge hammer to anything that is in my way. After my third panic attack, I took a 37.5 milligram Effexor and within the next few minutes felt amost instanteously better. Now I am having second thoughts about ever getting off of it. I was already used to the side effects since I have been on the medication for so long. I feel like I'm literally going crazy and I think my husband and kids both think I am also. I'm not sure exactly what to do, but I know that if I continue on the path I'm on, I will end up divorced and without my kids. I'm pretty much at a loss right now. Is there ANYONE out there with any kind of suggestions?? I'm not sure how much longer I can take this. At this point, my feeling is just to back on the Effexor XR and be happy again.