Depression Community
10.6k Members
Avatar universal

Has anyone tried Wellbutrin(Bupropion) Immediate-Release?

I've been taking Bupropion(generic) for 3 months. I've tried 300mg-XL, 2x150mg-SR, and both times (though I'd take the morning dose at 6AM) had a hard time falling asleep at night, tossing around in bed an hour or so. I normally don't have a sleeping problem. So, I now take only one 150mg-SR around 7AM and no afternoon dose. I can fall asleep fine now, but my energy runs out in the late afternoon ...

I'm wondering if I should switch to 2x100mg(immediate-release) instead, taking at 7AM and 2PM or so ... I heard that the effect of one dose should last about 6 hours, as opposed to SR lasts for 12 hours ...

If anyone has tried immediate-release, could you share your experience with me? Did it work okay (gave you energy and focus)?  Did you feel the side effects (anxiety, irritability, etc) were worse than XL or SR? Did your mood sink when it started to wear off?  
2 Responses
Avatar universal
Your mood will likely sink as the morning dose wears off in the afternoon if your system rids it then, which you mentioned. I don't think that med gives you energy though, so you should check with your pharmacist or doctor about that issue first to make sure you are not misreading the effects. The sleep issues could be related to your depression instead.
I tried it for a few months and dreaded what I called the 5PM "loss of color in my life" when everything would quickly turn bleak - is that what you meant by energy running out?
Avatar universal
Thank you for your reply. After taking 150mg-SR around 7-8AM, I feel fine till 5-6PM, but after that, I just feel tired and not wanting to do much of anything. For example, someone invites me to dinner or a movie early in the day and I'd accept it, but in the evening, I'm totally dreading the idea of going, sometimes making up an excuse to get out of the engagements ...

I think Bupropion is working for me better than SSRIs I tried in the past, but perhaps I haven't figured out the right dosage for me (as everyone's reaction to meds varies ...) Now I can get out of bed in the morning more easily and it keeps me awake all through the day (I don't feel like lying down in the middle of the day like I used to), but sometimes I feel overly restless and/or irritable, so added Prozac 20mg to offset the side effect of Bupropion.

I've had depression off and on for 15+ years, but insomnia was never a problem. On the contrary, I tend to oversleep when I'm depressed (total lack of energy and motivation). Bupropion is helping to correct that aspect.
This is beyond my knowledge but maybe someone else can help.
Have an Answer?
Top Mood Disorders Answerers
Avatar universal
Arlington, VA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
15 signs that it’s more than just the blues
Discover the common symptoms of and treatment options for depression.
We've got five strategies to foster happiness in your everyday life.
Don’t let the winter chill send your smile into deep hibernation. Try these 10 mood-boosting tips to get your happy back
For people with Obsessive-Compulsive Disorder (OCD), the COVID-19 pandemic can be particularly challenging.
A list of national and international resources and hotlines to help connect you to needed health and medical services.