370801 tn?1264405018

Is taking Wellbutrin XL and Sports Supplements together safe?

After searching the internet and coming up with nothing time and time again about this mix... I am left in a slight dilemma. Firstly,I take Wellbutrin XL 150 mg per day for depression. I find it is working well for me. It does not cause me to be agitated at all. In fact, I feel totally normal on it. It has had the opposite effect on me I find, making me more relaxed or sleepy at times. I take the Wellbutrin XL at 8am everyday.

By the time 5pm rolls around, I want to hit the gym. I live in dreary climate.. London, and I find I need something to help me weight train and have energy, get results etc. so I started taking a Bsn product some might consider controversial called No Xplode - ingredients listed below -- a nitric oxide / caffiene supplement. Reason why I am posting here is I really need a solid answer. I moved here from the U.S a few months ago and doctors here are not familiar at all with the drug Wellbutrin to treat depression - they seem to know less than me about it's effects and how it works.. so I can't ask my MD here.. I get my Wellbutrin from my dr. in the U.S - who I don't think would know what no xplode is over the phone.. So I need help from someone who knows..

I have not noticed any negative effects but I just started taking the n.o and i only take 1 scoop - the lowest dose/// I also take cell mass, a creatine supplement.. but I could cut that out if need be. Mainly, I find without the sports supplement I can't weight train properly and get good results - which in turn when I have a good workout and see results, I feel better in general, and happier - however, I am concerned about any long term effects or damage I might cause, with neuro transmitters etc. when combining these substances .. Here are the no xplode specs -- anybody know the deal? or know of a safer, better supplement for weight training / energy, muscularity etc?

"NO-Xplode is a Nitric Oxide boosting, muscle enhancing energy drink mix. The main component of NO-Xplode is its MetaFusion™ blend of ingredients. In this blend you will find the Nitric Oxide portion of this supplement, L-Arginine AKG. Arginine is a semi-essential amino acid. It is a building block of protein that performs a myriad of physiological functions. It is a known precursor of the gas nitric oxide [N02]. Arginine is the most important component of any NO supplement.

NO-Xplode also contains some Creatine, Caffeine and Nootropic Ingredients that help you focus on the task at hand.

NO-Xplode Ingredients

1.81 Lbs. Fruit Punch
Supplement Facts
Serving Size1Scoop(20.5g) ††
Servings Per Container40
Amount Per Serving % Daily Value†
Calories 30
Total Fat 0g 0%
Saturated Fat 0g 0%
Total Carbohydrates 7g 3%
Sugars 0g **
Protein 0g 0%
Vitamin B6(Pyridoxine HCL) 25mg 1,250%
Vitamin B9(Folic Acid) 400mcg 100%
Vitamin B12(Cyanocobalamin) 120mcg 2,000%
Calcium 75mg 8%
Phosphorus 500mg 50%
Magnesium 360mg 90%
Sodium 150mg 6%
Potassium 75mg 2%
N.O.-Xplode™'s Proprietary Blend 20,500mg **
(Contains A Patented Nutrient Suspension Matrix & Efforsorb™ Delivery System)
N.O. Meta-Fusion™(Patent Pending) **
L-Arginine AKG, L-Citrulline Malate, L-Citrulline AKG, L-Histidine AKG, RC-NOS™ (Rutacarpine 95%), Gynostemma Pentaphyllum (Gypenosides 95%), NAD (Nicotinamide Adenine Dinucleotide)
Muscle Volumizing Creatine Matrix(Patent Pending) **
CEM3™ (Creatine Ethyl Ester Malate), Di-Creatine Malate), Trimethylglycine, Glycocyamine, Guanidino Proplonic Acid, Cinnulin PF® (Aqueous Cinnamon Extract), Ketoisocaproate Potassium
Ener-Tropic Xplosion™(Patent Pending) **
L-Tyrosine, L-Tyrosine AKG, Taurine, Glucuronolactone, Methylxanthine (Caffeine), MCT's (Medium Chain Triglycerides), Vinpocetine 99%, Vincamine 99%, Vinburnine 99%
Phospho-Electrolyte Replacements™ **
Di-Calcium Phosphate, Di-Potassium Phosphate, Di-Sodium Phosphate
Glycerol Hydrating Polymers™ **
Potassium Glycerophosphate, Magnesium Glycerophosphate, Glycerol Stearate
† Percent Daily Values are based on a 2,000 calorie diet
** Daily Value not established
Other Ingredients
Maltodextrin, Natural And Artificial Flavors, Citric Acid, Sodium Bicarbonate, Sucralose(Splenda®), Acesulfame-K, Potassium Citrate, FD&C Red #40, FD&C Blue #1, Calcium Silicate

Label Warning
Individuals sensitive to stimulants should begin use with half the recommended dosage(1-2 scoops) to help access your tolerance. Seek advice from a health care practitioner prior to use if you have any pre-existing medical condition including (but not limited to): hypotension, hypertension, heart liver, or thyroid disease, diabetes, psychiatric disease, asthma, pernicious anemia, anxiety, depression, seizure disorder, cardiac arrhythmia's, stroke, difficulty urinating due to prostate enlargement, or if you are pregnant or nursing. Reduce or discontinue use if excessive sleeplessness, tremors, dizziness, nervousness, headaches, or heart palpitation occur. For use by healthy adults only. Not intended for use by persons under the age of 18. Keep out of reach of children. NOTE: Due to the translucency of the bottle, do not store in direct sunlight. Store in a cool dry place."
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Avatar universal
actually i have a similar question about this, my husband is on this medication bupropion, he wants to know before he starts taking C4 sports work out, that says doesn't have anything bad in it.  if it's going to mess with his meds?
Helpful - 0
585414 tn?1288941302
   As caffeine has a stimulant effect if a person discontinues taking large amounts of caffeine there will be withdrawal symptoms. To my knowledge they are not long term. However the stimulant effect can in some ways be a form of self medication. Even though caffeine has a mild effect it can temporarily worsen any form of psychiatric disability and certainly can cause or worsen mania (I know it did for me). Any treatment you are taking that is a natural remedy should be supervised by a doctor and as I do take some natural remedies which my psychiatrist approves (in addition to standard medications) some are familiar with their use. However as medications that are FDA approved are first researched for efficacy, side effects and overall safety and dosage guidelines often they are a better choice.. It would be worthwhile to discuss all this with a psychiatrist.
Helpful - 0
2054381 tn?1330458617

I took NO xplode (high caffiene 300mg plus many other ingredients and aminoacids) for 5 years. I became addicted to caffiene to get a feel good high.I was a very outgoing happy guy my whole life. before i knew it after 4 years on No xplode my depression kicked in, i had to quit all caffiene and stimulants, by 2010 i had crashed HARD, suicidal. I believe it has damaged my brains serotonin, dopamine, norepinephrine production. so i have starting taking 5htp, L-tyrosine. please comment wether this makes sense (high caffiene/ aminoacid intake for longterm can cause decreased production of dopamine, serotonin, norepinephrine.)  Thanks veryyy much. -Justin
Helpful - 0
Avatar universal
I know this is an old post but I feel like I should contribute since I take both NO xplode, wellbutrin, and concerta...and major in both neuroscience and psychology.

Wellbutrin alone usually doesn't do much, reason being is because its more of a reuptake inhibiter than anything. It acts specifically on dopaminergic and norepinephrineic neurons, thus letting DA (dopamine) and NE (norepinephrine) do their jobs longer.

Tyrosine and it's catalyzing enzyme tyrosine hydroxylase are precursors to DA. NO xplode plays big on this...by putting DA precursors in the mix, it allows itself to cross the blood brain barrier (DA cannot cross it, it must enter the brain as the precursors and then be processed into DA), add this to the fact that the NO vasodilates your system (including the BBB) it's safe to say that it increases DA production on a quick and significant level. Add that in there with your reuptake inhibitor for DA and you have a pretty potent synergistic effect.

You're time of day for working out with NO xplode is highly problematic due to sleep regulation issues. Simply put; this **** wakes you up. I take it and work out at 5AM in the morning and don't tire till 7PM.

I let a friend try a scoop once at work, she was little stimmed out, and then she told me "it was the closest thing to legal cocaine."...apparently she had done cocaine before. This is a fairly accurate comparison for someone who knew nothing about neurotransmitters/science.

Point being, you're probably not at any fatal IMMEDIATE health risks. But long term use (and high magnitude of scoops) will wreck havoc on your body and psyche. I know because it's happened to me a few times. Too much of this stuff might cause substance induced psychosis.

Do as I say and not as I do. Get off of it and eat a banana before you go to work out.
Helpful - 0
Avatar universal
LeftCoastChick & ILADVOCATE raise a really good point about so called 'natural medicines'. I'm sure you know already that a substantial number of regular medications are developed from natural sources (aspirin being a classic example), but are refined so only the active therapeutic agent is used. St. John's Wort / Hypericum is another good example - it works by pretty much the same mechanism as an SSRI (although the German medical fraternity think highly of it). The reality is that if a drug or a 'natural remedy' aids a condition, then their modes of action are probably similar (a ligand will bind to an appropriate receptor to produce the desired effect). The critical difference is that a prescription medication will have been tested for years before it hits the prescription pad; the 'natural remedies'? Well ...
Helpful - 0
585414 tn?1288941302
Tyrsosine alone is enough not to take it. It does indeed increase dopamine levels which is not a good thing. It made me psychotic for this very reason as well as raising my blood pressure to the point where if I hadn't been on Atenolol (for other reasons) I might have died. You really need to go off this "sports supplement" and yes research is good. Its just that half of the "information" out their on the internet and even some "self help" books are filled with misinformation. Every natural remedy is an unknown quantity. That doesn't mean some don't work but they must be supervised by a psychiatrist and some will do that (such as mine). I could give you some examples of what might work but frankly this sounds like a form of self medication so please go off it. Then if known anti-depressents don't you could speak with your provider about alternative treatments but take things under their supervision.
Helpful - 0
Avatar universal
So, do you want a real answer or justification for why you are taking it?

This stuff is dangerous in many ways, you are messing with your heart, endocrine system AND your mental health. I cringed at the list of ingredients. Many them can triggers some emotional side effects. You can work out without all those supplements, people have done so for years. You are also working out too late and messing with you sleep health.  Just because something is touted as natural does not mean it's safe, prime examples, St.John's Wort, Valarian, SAM-E.

Take normal vitamins if you aren't eating well enough, see a dietitcian. Taking these supplements are dangerous and not supported by the FDA (Food and Drug Administration) Wellbutrin is a common drug here, normally prescribed by psychiatrists, family doctors are not equipped to do so.  I would get a referral as well, to manage your depression.
Helpful - 0
370801 tn?1264405018
Medical use

Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine)[8] but has little if any effect on mood.[9][10][11] The effect on mood is more noticeable in humans subjected to stressful conditions (see below).
A number of studies have found tyrosine to be useful during conditions of stress, cold, fatigue,[12] prolonged work and sleep deprivation,[13][14] with reductions in stress hormone levels,[15] reductions in stress-induced weight loss seen in animal trials,[12] improvements in cognitive and physical performance[10][16][17] seen in human trials. Because tyrosine hydroxylase is the rate limiting enzyme, however, effects are less significant than those of l-dopa.
Tyrosine does not seem to have any significant effect on mood, cognitive or physical performance in normal circumstances.[18][19][20] A daily dosage supported in the literature is about 100 mg/kg for an adult.[21] The usual dosage amounts to 500-1500 mg per day (dose suggested by most manufacturers; usually an equivalent to 1-3 capsules of pure tyrosine). It is not recommended to exceed 12000 mg (12 g) per day. In fact, too high doses result in reduced levels of dopamine.[18] Tyrosine may decrease the absorption of other amino acids in high or chronic doses. It decreases absorption of l-dopa.
[edit]Drug Detoxification
Tyrosine appears to be a successful addition to conventional treatment for cocaine abuse and withdrawal. It may be used in conjunction with other amino acids such as tryptophan. Some individuals using tyrosine have also reported successful withdrawal from caffeine and nicotine.[22]

Helpful - 0
370801 tn?1264405018
I found this

"In the adrenal gland, tyrosine is converted to levodopa by the enzyme tyrosine hydroxylase (TH). TH is also the rate-limiting enzyme involved in the synthesis of the catecholamine hormones dopamine, norepinephrine (noradrenaline), and epinephrine.
The thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the colloid of the thyroid also are derived from tyrosine."
Helpful - 0
370801 tn?1264405018
Thanks guys for your answers and concern.

I feel the same way - Only that, I honestly can weight train much, much better when I have the energy drink, it also provides stamina and strength for my lifting, and I really need my work outs to feel good so, I'm still left to decide. Maybe one scoop 3 x a week , and a lot of water, ain't so bad -- I drink absolutely no coffee.

My main concern is that I hear that Tyrosine can effect dopamine  etc. And I am wondering if there are any known complications between a substance like this and wellbutrin etc. I wouldn't want to get serotonin overload syndrome or anything Iike that - tho I do feel super  happy and buzzed after working out, and no I don't crash from it either.. mood wise.

Also, not sure if Taurine effects neurotransmitters etc.

I guess I may have to do some in-depth research.
Helpful - 0
It’s been quite some years since this post was made but I’d like to throw some info out for you.
First: Not all pre workout supplements are bad for you. There are some that are more “natural” or “clean” than others. No Explode is not one of them. They have a notorious reputation for doing more damage than good.
Second: Creatine can have negative affects on your heart after prolonged use. It also pumps water into your muscles and that’s why you feel and see that pump. After a few hours the water disperses and the pump goes away. I would just cut it out completely if you can, though most supplements come with a small amount in them and that’s fine.
Third: Do your research for yourself and talk to your doctor! While you can get online and ask other peoples opinions, they are just that. Opinions. Even this post is a bit opinionated. Your doctor (if he’s a good one) should have some basic knowledge at least of how the different vitamins and and supplements react with different medications and if not they should research and get back to you.

You have to understand that everybody’s bodies are different and react differently to certain things. I have been taking Wellbutrin XL for about 6 weeks now and I use a pre workout 3 times a week and drink coffee or tea on non training days. I sometimes do feel a bit jittery but nothing so drastic that I need to quit taking either my medicine or pre workout.

I’m hoping that since this post the Dr.’s in the UK have learned more about this particular medicine and have helped you answer your question. If not, I totally understand the Dr. In the US problem, but I would still seek his/her advice before just jumping on the internet and taking a strangers advice.

I suffer from bi-polar disorder, anxiety, and a few other issues and am currently studying to be a physical therapist and personal trainer. I am no doctor so I can not give medical advice other than to talk to your doctor.

Hope this helps, isn’t too late, and if it is I hope it helps someone else that googles this question.
Doctors do not study supplements, so they will be of little help here.  Virtually any doctor will tell you not to take any supplement other than basic vitamins and minerals if you have a deficiency.  Allopathic medicine simply doesn't believe in it.  If you see a doctor who practices integrated medicine, you will find one who has studied both types of medicine, but there is not health professional whether practicing natural medicine or allopathic who will approve of taking any sports supplement.  For one thing, they do nothing for your health, and they have no necessary function.  Virtually none of them actually have been shown to work all that well.  The ones that do work are mostly laced with steroids that are not listed on the label, and it's the steroids that work.  Most people who take them also take steroids.  This is a field that has been researched to the ends of the Earth, and this is just the truth, not an opinion.  I spent most of my career managing health food stores and so I sold a lot of sports supplements, and so I've seen the research and the results and I also know that the bodybuilders and athletes were also using steroids.  So what do the sports supplements actually do that works?  Additional protein will help with recovery after a workout and help build muscle, but at the cost of possible problems of taking too much protein.  Creatine does seem to work some, but the greatest danger of it is the same with using too much protein, which is kidney damage.  The other thing in them that works are the stimulants, usually caffeine.  That allows you to work out longer.  But you know, if you're having a mental illness that's a really horrid thing to live with, whereas not having big muscles is actually good for you because the body doesn't require as much food to keep those muscles and less food is a good thing.  Everyone gets to decide how to live their lives and what's most important to them, but an athlete who isn't a professional and is regularly training should really be full of energy by virtue of doing that.  So yeah, some of the things in this stuff does a little bit for you, but more harm than the good.  Nobody takes them for health, they take them for performance, and if you don't make your living from it, why bother?  Wellbutrin is a very stimulating drug on purpose.  When you take it you are amping up adrenaline.  If you suffer from anxiety, this can be a problem, but if it isn't, good.  If it works, good.  But my view is, and this is opinion, as there is no expert advice to give on vanity, why risk working against the med and making your condition worse?  It's just exercising caution; it doesn't mean everyone will have a bad reaction.  But to repeat, there is no necessity in taking stuff that marketing is the only thing positive about the stuff.  Peace.    
Well, left out electrolytes.  They are also helpful if you're not getting them in your diet and they are in a form that is well absorbed, which they seldom are, and you take them with food.
Thanks for the info NinhaSteve.  And paxiled. There are always different perspectives and everyone has great experience to share.  May be different from someone else's point of view or opinion, but equally as correct based on what we ourselves experience. My own doctor, quite intelligent, brilliant even has an interest in holistic, natural medicine and supplementation. She's worked to know a lot about it and to share with her patients.  I think that is more and more common than decades ago.  Integrating lots of approaches is much more the norm now.  Good info, thank you
Avatar universal
The post above is spot on. The supplements you buy from 'Holland & Barrett' or wherever you get them tend to be poorly researched and their mode of action is usually not fully understood. It's likely there's no research specifically investigating how your supplements may affect the metabolism and excretion of your Wellbutrin. Most of the research also seems to suggest that proprietary supplements are of little or no benefit to your training. Go clean - it's foolhardy to train to improve your health whilst augmenting your training with junk that could give you long-term health problems.
Helpful - 0
585414 tn?1288941302
The "sports supplement" is unsafe in itself. I strongly suggest you stop taking it. I am going through the ingredients and tyrosine in itself in me caused me to have dangerously high blood pressure. Others of those ingredients are useless. Take a standard vitamin and mineral supplement. Tyrosine and taurine and many other things you will find in the local health food store are outright dangerous. There are some natural remedies for use in depression that are somewhat of help but they should only be taken with a psychiatrist's supervision. What you are describing is not one of them. I'd strongly suggest that you not take it, its probably doing more harm than good if any good at all. Its an unknown quantity which is never a good thing.
Helpful - 0
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