Depression Community
10.5k Members
Avatar universal

Pristiq , Wellbutrin or Cymbalta for bad depression?

Following a bad car accident, I have been dealing w/ terrible anxiety and ptsd. Besides my pain med and muscle relaxer, I take Klonopin 3 mg day. I have an appt. set w/ my reg. doctor to go over how bad my depression is. Most my depression I know stems from being extremely active and now 9 months later dealing w/ a terrible back/neck injury and pain and I can't be physical. My motivation is 0!! I go to all my PT appts and Chiropractor, etc. It feels hopeless....It may seem stupid, but ski season is coming up and now I was thinking this will be the first time in 15 yrs. I prob. won't be going. I just want to stand for 20 min. w/o pain in my upper back/neck. I'm beyond frustrated!!!
Anyway, the question?? A big question I have is feeling worse? Weight gain?(since I can't workout,might seem vain...but it will only depress me more) How long it takes to kick in? Mixing w/ Klonopin? I understand these our real ? for my doctor and everyone is different...just wanted some feedback.

Thanks in advance
8 Responses
Avatar universal
Most of all of any of my Drs. have always told me that it usually takes at least two weeks for you to start feeling better once you start on any new med for depression. I would give it a little more time and try to think positive that it is going to help. The mind can be a powerful thing, look how it can sometimes react to just a placebo. If you still are not feeling better in a week I would contact your DR., maybe the dose needs to be increased. When you had the bad car accident what caused your main downward spiral, were you or someone else badly injured, or was the vehicle you were in totaled and cannot be replaced, were you the driver, was it your fault? There are many variables I don't know about, maybe talking about what happened can not only clarify things for you, but for me also so maybe I can help you more as I would love to be able to do that. ahelping others validates my reason for being here and since I can't work as an RN anymore I need to still help if I can. Ihave tried Cymbalta, didn't do anything for me, also Lyrica for fibro, still no help, I'm not sure if I have tried Pristiq but have been on almost every med for depression, stay with the Wellbutrin because as I previously explained, It doesn't make you tired, also is know not to have sexual side effects(most decrease your libido) and if you smoke or use tobacco products it contains the same properties found in the drug they prescribe to help quit; so that may be an added bonus for you. Hope I answered your initial question and maybe have given you more info you weren't aware of. If you want to explore your depression more I am a good listener, don't mind hearing about how far you are down, would like to help pick you back up, just need more info from you. Hang in there please, this time of year is stressfull even if you have no problems, and for those of us who do, it just makes it worse. Try and think about the real meaning of Christmas and if you can surround yourself with positive people. Hope to hear from you, Tired55
Avatar universal
  Hi there, so sorry to hear of your troubles. I can emphathize and sympathize with your situation, been there for a long time. If you are worried about gaining weight I would pick Wellbutrin as it is not known to cause weight gain,also won't make you as tired as some other antidepressants. Don't know about how it will react with your Klonopin though,good question for your Dr. or pharmacist. Hope this might help a little.  Good Luck, Tired55
Avatar universal
Thank you. I have my appt. with my Dr. next Thursday, Wellbutrin was what I was leaning towards. Feeling tired all the time is also a big problem..thanks for adding that in.

Take care
Avatar universal
I used to take Cymbalta (Duloxetine) for sleeping problems associated with depression; Cymbalta should never be given to people with anxiety! As that would just make the anxiety worse... the same reason why people with mania such as Bipolar sufferers shouldn't take the stuff.

Also, I struggled to hell with the side effects of Cymbalta! Coming off of the stuff took me MONTHS - though that is an extreme example, apparently most don't get such issues.

So my advice (as not knowing much about the others) is don't go with Cymbalta...


- John -
Avatar universal
Been on the generic Wellbutrin 150mg for 9 days.......any idea how long these things take? I'm in a downward spiral....my doc said this is quick acting one, she said should feel it within a week.
Avatar universal
I doubt your dose will be increased unless you start to get some positive effect from it. I was told W can take 8 weeks for the full effect, so I imagine doc will be reluctant to increase the dose in your trial period.
Have an Answer?
Top Mood Disorders Answerers
Avatar universal
Arlington, VA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
15 signs that it’s more than just the blues
Discover the common symptoms of and treatment options for depression.
We've got five strategies to foster happiness in your everyday life.
Don’t let the winter chill send your smile into deep hibernation. Try these 10 mood-boosting tips to get your happy back
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.