Hi. I'm on tamoxifen so I can't take any meds which inhibit cyp2D6 enzymes. I've been on almost ALL SSRI ( Effexor, lexapro, celexa, nortriptyline, fetzima, & viibryd) & my depression worsens with them (suicidal thoughts, etc). The only one that has helped is remeron but every time I've had to return to remeron I gain weight. I'm usually 110-112 and eat very well & workout almost everyday. With remeron i have gained 5# per month & every time have wuit after 4-5 months then the weight falls off & goes back to normal. In my teens I took serzone which worked very well. I had NO side effects back then. My doc is thinking we will try serzone. Does serzone work similar to remeron? If remeron works will serzone likely work when all these others just make me worse? I'm so frustrated.