I'm a 53 year old female with a family and personal history of depression. I've been on Wellbutrin SR 150 mg. once a day for the last 5 years, and have done pretty well on it, with the exception of some episodes of intense sweating, but nothing I can't handle. About 2 months ago, in the middle of some very heavy work and marital problems, I went into a very frightening depressive state--more intense than I had experienced before--being scattered, agitated, anxious, forgetful, having difficulty falling asleep or staying asleep for any length of time, pacing, crying for no apparent reason, and a lot of dark thoughts that were scaring the heck out of me. My doctor ordered me off work for three weeks, doubled my Wellbutrin and referred me to a psychiatrist, who finally contacted me this past week and will be able to see me in mid-June (!). The intense stress in was experiencing in all aspects of my life was just too much and I guess the whole serotonin thing went seriously out of whack. After a couple of weeks on the 300 mg. dose, I began to have agonizing headaches, extreme insomnia and became twice as scattered and forgetful. My pharmacist said it was probably serotonin sensitivity and my doctor put me back on the 150 mg. and prescribed Trazodone to help me sleep. It took a couple of weeks, but I began to sleep well, but started waking in the wee hours with searing headaches. I've just finished up the Trazodone and I'm taking an herbal plus melatonin sleep aid, which is not as effective as the drug and not getting me through the night, but it will do. The headaches continue, and I'm starting to think I'm losing my mind because I'm more forgetful and inattentive than before. I'm having memory lapses that are starting to scare me, like going to the bank to deposit my pay cheque, signing something and putting it in an envelope and depositing it, then discovering a week later that things are bouncing and finding the cheque in my dresser, unsigned. I'm driving places and find myself wondering how I got there and what I'm there for. At work people are asking or telling me things and I don't remember or can't answer and I feel like an idiot half the time. This is especially frustrating for me because I'm a teacher, university educated, with a high IQ and, normally, a phenomenal memory. I desperately would like to know if this is still depression rearing its ugly head, or if my brain is still trying to shake off the double dose of Wellbutrin. I am still under intense stress and trying to make some job changes, but I'm at the point now where I'm considering going on medical leave for a while in an attempt to get myself together and be normal again. Has anybody else experienced this and will it pass, or am I in this for the long haul? Any input or advice would be most appreciated.