Depression Community
10.6k Members
Avatar universal

Wellbutrin and Lexapro together

Has anyone ever tried this combo?  Did it work for you?  My doc wants me to take Lexapro 10 mg for panic disorder and depression but I get sooo tired and told him that I'd need something more energizing to keep me going and get me off the couch, Wellbutrin XL works wonders in that regard.  I haven't heard from the doc yet...maybe he thinks I'm crazy lol.
4 Responses
1326846 tn?1311215111
I am on that combination and it works great.  I was taking Lexapro 20 mg with Wellbutrin and was fine.  How long have you been on Lexapro?  My doc started me out slow with a week of 5 mg then 10 mg and so on.  I know jumping into 20 mg for me was exhausting.  Best of luck.
Avatar universal
I haven't started the Lexapro yet. Scared of all the side effects, I'm on Klonopin 1mg/day and it's fine but weak.  Still get very anxious just not panic attacks.  I can't sleep at night so the doc thinks Lexapro would calm me down even more.  

I have a very stressful job and deal with clients all day so obviously being lethargic, sleepy, or even more overweight from that Lexapro is not an option ;)

Stay in touch - I'll let you know what the doc says.

Avatar universal
Hey 425runner,  I started the 10mg of Lexapro and 150mg of Wellbutrin about 3 weeks ago.  The overwhelming fatigue and sleepiness was/is almost unbearable.  I have also suffered lately from feeling severely out of touch with reality and my surroundings and not being able to focus on things at all, staring off into space. My husband says I am always in another world even when I am sitting right next to him.  I'm feeling the depression has possibly worsened.  Tell me, did you experience any of these other side effects when you started?  I am considering coming off of it because of these terrible issues, but I am wondering if I should stick it out a little longer and see if things improve.  Advice?
Avatar universal
was considering this if the venlafaxine stops working with me in time. good to read peoples opinions / experiences with the combination. ni204 - give it some extra time if you can as the 4-6 week therapeutic window for antidepressants is a rough estimate sometimes, give a little longer possibly but if your not feeling any lighter in mood at all then speak to those involved with your care i'd say. It's like this owing to the severity of one's depression & due to possibly the somewhat random possibility that this choice of meds may, may not be the ones that work for you. Hang in there and be gentle with yerself.
Have an Answer?
Top Mood Disorders Answerers
Avatar universal
Arlington, VA
Learn About Top Answerers
Didn't find the answer you were looking for?
Ask a question
Popular Resources
15 signs that it’s more than just the blues
Discover the common symptoms of and treatment options for depression.
We've got five strategies to foster happiness in your everyday life.
Don’t let the winter chill send your smile into deep hibernation. Try these 10 mood-boosting tips to get your happy back
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Here’s how your baby’s growing in your body each week.