My husband is a doctor. He was diagnosed with mod-severe clinical depression at age 25. He is able to get zoloft and ativan for himself and has for years. He has no psychiatrist/therapist and refuses one. He gets angry easily, verbally abuses, has such misperceptions it is amazing. Communication is soooo difficult. MY QUESTIONS:
Does Zoloft become less effective over time or are there chemical changes that call for a dosage change?
Do people -being successfully - treated exhibit irritability, unreasonable perceptions and anger?
Is impulse control effected?
Does the brain actually change after years of depression/treatment by any chance. My husband has taken antidepres. for 25 years.