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Avatar universal

Zoloft vs Wellbutrin

I am a survivor of an abusive marriage of 28 years and a major heart attack.  The doctor insists that I must stay on antidepressants for the rest of my life.
I gained 40 pounds while taking Zoloft and yet I can't cope without some sort of medication nor can I cope with this weight gain.  I have always prided myself in looking nice. I have just switched to Wellbutrin XL because I heard it doesn't cause that weight gain that Zoloft does...

Can someone pleae tell me if they have gone through this and what I should expect?
7 Responses
Avatar universal
I just tried Wellbutrin because I read that it had fewer side effects than others and may help lose weight (and I had just tried Cymbalta and Effexor and didn't like the side effects)...I was a little hesitant to try Wellbutrin since I had success with Prozac in the past, which works on Serotonin (like Zoloft) and Wellbutrin works on Dopamine (a completely different drug)...well I have to say, after 3 tough weeks of severe nausea, lightheadedness, dizziness, headaches, and dry mouth, I had to stop Wellbutrin and will be going back to prozac.  If Zoloft helped with your depression, than there is a chance Wellbutrin won't work, because the brain chemistry problem that needs to be addressed is the serotonin problem.  I hope you have better luck than I did.
962875 tn?1314213636
Wellbutrin CAN be helpful even when people have previously had a good response to an SSRI (Zoloft, Prozac, Paxil, Lexapro, etc.). It does have some serotinergic effect, as those meds do, but also works on a different neurotransmitter and may give you more energy. A big plus is that it generally does not  the negative sexual side effects that may accompany the SSRIs, and in some people it increases sexual desire where this has been lacking.

The only way you'll know if it's a good choice for you is to try it.

It is also possible to combine a lower dose of an SSRI that has been helpful (to lower the chance of weight gain and other side effects) with Wellbutrin, to get the benefits of both types of medication.

Best wishes...
Avatar universal
I think doctors really ignore the fact that these drugs work on different neuro chemicals.  Usually if you have panic attacks, and are irritable, have OCD and are depressed, an SSRI would be better than Wellbutrin (Wellbutrin can make panic attacks, irritability, anger and OCD even worse).  

I am convinced I have a dopamine problem, which is why I didn't even CONSIDER an ssri.  I went right for wellbutrin since it works on dopamine.  Well...let's just say, my doctor started me off very high (450mg) and my severe suicidal thoughts and absolute utter hopelessness and depression and blankness that I have had for over 3/4 of my life is gone.  But, I have noticed that Wellbutrin feels like you are on a drug...things are very hazy while you are on it, like it is dream like.  Like you are doing things...but you don't really care that you are doing them.  You just are doing them.  

My destructive and dark thoughts are gone.  I can barely even thing up bad thoughts to make me depressed (I tried as an experiment) but the thoughts did not gain friction.  But you KNOW you are on a drug with this.  

For the lack of energy and extreme robotic apathy, I got severe irritation, agitation.  I also cannot sleep with it.  I am going to have to get a sleeping pill.  The good news is, if you wake up and are tired, you take some wellbutrin and you aren't tired anylonger...it is like caffeine, not so much speed.  It isn't like overpowering energy, it is like you are awake and not tired.  Very difficult to go to sleep.  

And the pill makes you NOT want to eat.  It is like food isn't as pleasurable anymore (and I was obsessed with food before).  This doesn't suppress your appetite though, it just makes you not want to eat.  
Avatar universal
Wilkes,  just read your post. It's pretty good BUT pls be mindful of judgements. Some people who reads these are at wits end and any so called educated opinion can have a drastic effects.  
Zoloft or Wellbutrin can be a good or bad drug it is a individual case.  
Wellbutrin has been helpful for me in regards to depression as well as weight loss.
480448 tn?1426952138
This thread is over 5 years old.  The person you've addressed is not active on the site any longer.

Please be mindful of dates when you pull up a thread.  You will notice that there is a little hourglass icon next to the date.  When you see that, it indicates that the thread is over 6 months old.

Thank you.
Avatar universal
I have switched from Zoloft and Bupropion for the past 6 years. As I have gotten older from 23-25 I have felt that Wellbutrin doe snot affect me the same way as it did before. I want to switch back to Zoloft but I am not sure. My best advice is get 2 opinions from being evaluated. Trust me.
612551 tn?1450025775
Mindful of "Nursegirl..." and saying I was just about to comment on the very old thread, I am about to start generic Zoloft and am here looking for exerience with Zoloft.  Maybe the original post will give me some useful on Zoloft.
My wife is taking generic Zoloft; 50mg.  She has no interest in sex. None.  I feel like our marriage is going down the toilet.  Has any woman here switched from Zoloft to another anti-anxiety medication that has improved their sex life?  My wife and I are both 60 and in good health otherwise, but this is really getting to me.  Any suggestions would be appreciated.  Thank you in advance.  
Wellbutrin is the only one I know of that doesn't make you lose your desire to have sex.  It also does not cause weight gain. I have been on a low dose 150mg I take in the evening. I wake up refreshed not groggy and don't have overwhelming medicine head throughout the day, but that low dose keeps my moods even. Have been taking this for 13 years.
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