I've been battling major depression for almost a year, I'm not BP. My Dr has been upping my meds. I did ok on effexor xl 150mg and lamtical 100 for 2 weeks and then crashed really bad. So my dr upped my effexor to 225 mg and for 2 weeks felt normal for the first time in a year it was a relief. Then I had a international gift show to work, this was working 12 hour days for a week and then I started my period. Then I had to leave this job and go on a family vacation the very day. I've been having anxiety and bouts of depression. My Dr is on vacation and the dr on call isn't getting back with me. Any thoughts would be great! I know he'll up my meds I guess.