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Avatar universal


I've been on paxil for about 4 yrs,for my anxiety and depression, it has worked wonders for my anxiety, but lately my depression has got worse and just feeling uneasy,unmotivated. I go to my doctors in a couple of days and want to try a new depression med,but am afraid my anxiety will come back. What meds should I try. Ive been on
Lexapro twice first time it worked quit it and started it again when I had my first anxiety issues,didn't work for my depression.
Effexor- intensified whatever mood I was in.
Zoloft- same as effexor
Anxiety meds
Buspar- didn't help

Finally my doctor put me on paxil and monitored me on ativan for breakthrough,which I went from taking a few times a week to now few times a yr.
So my question is stay on paxil and is there a depression medication I can take along with it?
6 Responses
Avatar universal
Most anti-depressants tend to "poop out" after a few years in about half of those that take them.  This is in part due to the brain finding a work-around on the medication so other steps are taken to get the depression/anxiety back in check.  This problem is commonly fixed by adding medications such as Abilify to the original anti-depressant.  Personally, I would not add these type of meds to Paxil unless you have not had any weight gain issues during your time on in.  I prefer to add the class of medications such as Abilify to the SSRI's;  Lexapro, Celexa, or Zoloft.  I know that you stated that these did not work work for you in the past, however, when the second agent is added to them they become a very effective anti-anxiety/anti-depressant combinations. One other piece of information you need to have if you ever switch off of Paxil is that it is very possible that you can have withdrawal side effects, so hopefully your doctor will move the new one in as you slowly come off of it.  I say this so that you do not stress or panic if this occurs during the transition. There is light at the end of the tunnel.
Best of luck
Avatar universal
Thank you very much for response. Yes the weight gain has been an issue on paxil so is  abilify known to cause weight gain as well?
Avatar universal
I suggest that you take Zoloft for anxiety and not to add any other combo to overcome depression for which you can try rtms
Just google it you will get more info
Avatar universal
Where do you live
Avatar universal
My experience is that those taking Paxil that noticed weight gain, could also have issues with additional weight gain taking Abilify. This is not a certainty, but I would put the odds at slightly better than 50/50 that it may occur. Even if this is the case, a few extra pounds would be worth your sanity. Talk to your doctor about the many choices based on your own physiology. Any pre-existing conditions will come into play if/when your doctor makes changes to your med list.

Avatar universal
If you add wellbutrin it will likely limit your weight gain and is a pure antidepressant, but it can be stimulating and so it's theoretically possible it will increase your anxiety.  Paxil is a difficult drug to stop taking, and once you've taken it because it seems to be stronger in its affinity for serotonin and choline receptors it's sometime difficult for other drugs to work.  If it's still working for anxiety, I'd probably stay on it because it's so problematic to stop taking and try to deal with your depression through therapy since it doesn't sound debilitating as much as just lessening your life.  I've always found the anxiety to be a lot worse problem than depression.  Good luck, and if you do decide to switch, don't let the doc rush you off the Paxil.  Taper off very slowly, a slowly as you need to, and don't start a new med until you've completely successfully stopped the Paxil so you don't have two drug's side effects to worry about at the same time.  It's very hard to evaluate a new drug if you're withdrawing from the last one.  Peace.  
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