Hi, I'm in agreement with everyone else, the dose should definitely be increased, it is quite normal after 3 or 4 weeks for the doctor to increase the dose, as now at 6 weeks you will be feeling the full effects.
You will definitely feel the difference if it is increased, Zoloft is really good for giving energy.
I get very irritable too, I think it is frustration. I get fed up with myself, and then I get annoyed with everyone else too.
As the treatment starts to work and you have more energy for life, you will feel better.
Go see your doctor, its always a good idea to go back for a review of things, the doctor will be pleased that you have felt some effect and will more than likely increase it, he will have started you on 50mg so that you won't have had too many nasty side effects.
Things will get better soon, depression requires small steps unfortunately..
Take care
I agree with AJRC323 and lilymoon. I think Zoloft is a great medication and I started at 50 then went up within a week and a half to 100mg. The jump from 50 to 100 seemed make the biggest difference. Although 50 was helping me and kept me from getting "too deppressed" 100 was what made me start to feel like less of a failure and I credit it with greatly benefitting my mental recovery.
50 mg is a low dose since you say it does help a little I would discuss maybe trying a higher dose with your doc,I personally think its better to really try it before you switch to something else.Lily
If you're experiencing a benefit at 50mg, talk to your doc about going up to 100mg. 50mg is a low dose, so it's a good sign if you're getting some benefit from that.