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HPV and psoriasis

I was prescribed Aldara (imiquimod) to get rid of a few perianal HPV warts since cryotherapy was only making it worse.  After only about 2 weeks of usage almost all symptoms of the warts were gone however I now have perianal psoriasis in its place.  That is one of the side-effects of imiquimod and it mainly strikes people whom are genetically prone to having psoriasis.  It is known that an overactive immune system can trigger a site of psoriasis, and imiquimod invokes an immune response to have cytotoxins destroy skin cells.

So now.... retinoid treatments are not helping, and the only other main treatment for psoriasis are corticosteroids which if I'm not mistaken are immunosuppressants lol.....  are they not?   If I start using those then HPV will form new warts....  on the other hand, it would be a neat experiment.... if there are no new warts, then that's +1 for Graceway Pharmaceuticals who claims they are uncertain if Aldara causes HPV to be killed off completely or only to some extent.

so... what am i doing? pursuing corticosteroids and calcipotriol?  or maybe try just calcipotriol on its own to begin with?
2 Responses
Avatar universal
An uncommon form of human papillomaviruses (HPV) called EV-HPV has been associated with psoriasis. Although EV-HPV is probably not a direct cause, it may play an indirect role in the perpetuation of psoriasis. This HPV form is not the virus associated with cervical cancer and genital warts.Corticosterods applied externally do not cause any significant immuno suppression.Remember our own body has to get rid o HPV and Aldara can not possibly get them by itself.
Avatar universal
Yes, I'm not saying that Aldara acts on HPV itself.  It is indeed the body's own immune system that gets rid of HPV-infected cells, however since the virus is not systemic and lays on the outskirts of your skin, it is hard for the immune cells to detect it and excrete cytotoxins that destroy compromised cells.  That's why Aldara is marketed as "killing HPV from the inside out".  The imiquimod is absorbed into the skin deep enough where it reaches immune cells and causes them to excrete cytotoxins in that area so any and all skin cells around there start to get destroyed by your own immune system, all the way to the outside of your skin (from the inside out).

Anyhow aside from all that... I'm going to use a very mild 1% hydrocortisone cream and go from there.
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