Approximately 10 percent of patients present with psychiatric problems ranging from subtle personality changes and deteriorating performance at school, to overt depression, paranoia, and catatonia.
There may be a possibility that the depression in your case isn't associated with Wilson's disease. To further determine this, you may want to confirm whether you have the disease or not. Patients in whom Wilson's disease is suspected should undergo initial screening with liver biochemical tests, a complete blood count, serum ceruloplasmin, 24-hour basal urinary copper, and slit-lamp examination for Kayser-Fleischer rings. You may want to discuss these tests with your personal physician.
If the depression is truly from Wilson's disease, then it would be less likely that it would respond to traditional psychiatric treatment.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
Kaplan. Diagnosis of Wilson's disease. UptoDate, 2004.