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eosinophil gastroentrenitis

  My 15 year son weighs 95lbs and is 5'1". I originally took him in because he was not growing.  Subsequent testing including CBCs
  endoscope and barium swallow indicated severe esophagus constricture and eo count (over 45%). Tissue biopsy indicated
  high eo infiltration. Multiple stool samples ruled out parasites.
  Allergy testing indicated multiple food allergies.  He has been on a strict diet for two months and had a repeat CBC - now eo count is over 53%!  Any ideas?  Other complaints were bad breadth and spontaneous vomiting (3 -4 times a month).
  Thank you!
Dear Nancy,
Eosinophilic gastroenteritis is a condition in which there are eosinophols infiltrating different regions of the GI tract and different areas of the wall (mucosa, muscle or serosa) as well as a high blood eosinophil count.  It is necessary to exclude infections, allergies, hypereosinophil syndromes and colllagen vascular diseases as the cause of the eosinophil proliferation.  Elimination diets may help if a specific food allergy is identified.  Corticosteroids, sodium cromolyn ( used in asthma) and ketotifen have been reported to improve the condition of patients with eosinophilic gastroenteritis.  It will be necessary for you to work closely with your physician to determine the best diagnostic and therapeutic approach for this problem.
Although it is difficult to know the cause of your sons symptoms, one could speculate that malabsorption (due to eosinophilic infiltration of the small intestine lining) is the cause for the failure to grow, esophageal infiltration is the cause for the stricture and gastric muscle infiltration with delayed gastric emptying is responsible for the vomiting.
This information is presented for educational purposes only.  Always ask your personal physician questions regarding specific medical issues.
*keywords: eosinophilic gastroenteritis

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