My four yr old german shepherd mix is sick for the third time since December. We have been to UC Davis three times without any answers as to what is making her so sick. 1st visit 12/22/16 2nd visit 2/21/17 3rd visit 3/8/17. At this point the possibilities we have left are 1) Infection. Possibly in her spine or bones. 2) Immune-mediated 3) Inflammation 4) cancer. She has taken fluids well and tolerated her ABX’s up until this go round. Her symptoms are the same every time. 1) Fever of unknown origin (usually 103+) 2) Lethargy periods (she perks up when you take her for walks, trips to the vet, outside and the neighbor dog comes outside) 3) Loss of appetite (this time more severe than previous) and she seems to not want to chew or put things in her mouth. We have also noticed that sometime in the last two weeks she has broken a tooth. She was eating her normal kibble until the fever started again.) 4) Not wanting to shake her head (like when dogs are wet to dry off) 5) diarrhea with mucus. Color is an orangy-reddish clay color. No clumps or strands of blood. 6) NEW SYPMTOM Mucus. She seems to be swallowing often almost like it is hard to get anything down. She vomited today about 30 min after giving her Baytril and it was a very thick mucusy foam. She also threw up last night about and hr and a half after giving her clavamox but that was just fluid. She has been prescribed Clavamox 375mg BID and Baytril 68mg 3tabs QD. Normally she tolerates these fine but she has not been eating or drinking like she normally does. I have been pushing fluids and have tried chicken/rice, wet dog food, bread soaked in milk, and bone broth and she doesn’t want to eat anything. I have had to force food to give her pills.
We have done blood work three times.
WBC’s 1)10,900 2)11,802 3)3,039
Bands 1)654 2)1,180 3)760
Neutrophils 1)8,611 2)8,379 2)912
Monocytes 1)1,199 2)1,888 3)669
Platelets 1)112,000 2)122,000 3)314,000
Creatine Kinase 1)568 2)307
Alkaline Phosphatase 1)206 2)328
BUN 1)8 2)9
We’ve done a 4DX Snap test which was negative. Two Urine analyses were negative. Echo for Grade 1 heart murmur came back normal suggesting her murmur is physiologic. Chest xray was within normal limits as well as her spine. Abdomen ultrasound showed a mildly dark liver and mottled spleen. A liver aspirate showed inflammation from possible production of WBC’s. No infectious agents were noted. Final review is still pending. A blood culture is also pending.