You know, my husband also has a missing bone between sinus and brain. Just a small fragment and no one knows why but it was after sinus surgery when they informed him of this. There is something about the consistency of egg white that separates them. Kind of freaky. Anyway, this is a good question for your doctor. I wouldn't think this should be an issue but you'd want to make sure you have just the right pressure setting for your cpap device. You'd also want to pay attention to sanitizing the machine. Why have they told you to use the machine? What's your condition? Sleep apnea itself can have negative implications for brain health. The bacteria that they talk about with cpap machines is more lung related. But talk to your doctor.