I would like to understand from other users, what is a normal response time for a strep sore throat to heal. Had a progressively worsening sore throat for 3 days, rapid test positive for strep. Started Zithromax 500mg per day for 5 days due to penicillin allergy. Now starting my 3rd day of treatment with no change in pain status. Have gargled every few hours with salt or apple cider vinegar; no relief. Should I become worried? I read that usually symptoms clear up within a day once starting a/biotics. Any help or input would be appreciated. I just want to understand what the variation exists in managing the sore throat.