7-methylxanthine (7-MX) Drug in US

[kitty15]

I am interested in 7-methylxanthine (7-MX) drugs for my 2 boys, 9 &10 whose both have myopia and get worse each year.   And would like to know where could I get the 7-methylxanthine (7-MX) in Los Angeles, California US.    Please provide the contact or doctor name in Los Angeles.  If not available in Los Angeles,  please provide other contact.

Many thanks.

Yuen

[flossy93]

The link you posted to Dr. Trier's email address was edited out by the filters on this web host.  Can you re-write the address with 'AT' rather than the '@' symbol to see if that helps?  Or paste in a link to a website showing the email address?

I tried researching Dr. Trier's latest activity a few months ago but couldn't find any additional info about followup trials, using 7-MX in adults, or anything else about it.  

[naveenasubbu]

This is Klaus trier's email ID  "***@****"  Is this the one you tried?

[flossy93]

You might be interested to learn that the University of California at Berkeley opened a new myopia control clinic this fall for children and adolescents.  

Here is a link to the news story about this new clinic.  The article includes the clinic email address and phone number if you want to inquire about your specific concerns.

http://newscenter.berkeley.edu/2013/08/28/myopia-control-clinic/

If there is any source of 7-MX in the US, especially a clinical trial, I would expect them to know about it, since this new clinic serves the pediatric population with worsening myopia.  Good luck!

[flossy93]

At least now you know that Dukey's surgeries both went well and his vision has been stable (aside from two Avastin injections), per the update I posted a few days ago.  That was good news, even if the 7-MX problem is still unsolvable for those outside Denmark.

Good luck with the decision about the laser vs traditional cataract surgery.  I know it's a difficult call.  From what I've read the experience of the surgeon is the most critical.  Two different ophthalmologists have also told me the laser-based procedure is safer for high myopes and better for patients getting multi-focal implants.  But at least one doctor on the MedHelp-Doctor forum said he did not agree.

[ValveJob]

Thanks for the info regarding Dukey.  I messaged him a couple of years ago, and he never answered, so I thought maybe he had tried something like scleral pole buckling and that something had gone horribly wrong.  It is discouraging to hear about the expense of 7-MX and the difficulty in getting it.

I may re e-mail Dr. Trier once I have gotten my cataract problems out of the way, although if the stuff is that expensive and difficult to get, maybe it is not worth it.

[flossy93]

I'm sorry to hear Dr. Trier did not get back to you the second time you tried to contact him.  Might be worth forwarding that email again, just for one last try.

BTW I searched on the FDA website and also on Google and could not find any information about trials for 7-MX in the US, or any mention of it at all except for Dr. Trier's study.  In the event you do find any information about it, it would be great if you could post a link on MedHelp.  

Also I messaged Dukey last week to ask if he was still taking 7-MX.  He said he had stopped because it was very difficult to get and quite expensive.  He said if it was easily available and inexpensive he'd probably take it even though there isn't any evidence of efficacy in adults, but that given the current problems obtaining it he is no longer using 7-MX.  Sorry I can't help you with this.

[John C Hagan III, MD, FACS, FAAO]

-

[ValveJob]

I e-mailed Dr. Trier at the beginning of 2012.  Below is our correspondence (I deleted my name) with his answer to me on top:

Theoretically, the treatment may work on adults, but I have only a few of these cases in treatment and as yet no data available. I should be able to say more in about a year from now.

Regards,

Klaus Trier, MD

From:  
Sent: Monday, February 20, 2012 3:03 AM
To: Klaus Trier
Subject: Adult pathological myopia

Dear Dr. Trier:

I have read about 7-methylxanthine for childhood myopia, but I am wondering if it has been tried in adults with pathological myopia to prevent further axial lengthening.  I would be willing to go to Denmark for a prescription and for obtaining the drug.

Thanks in advance.

I wrote him again at the beginning of this year, but he never e-mailed me back.

[John C Hagan III, MD, FACS, FAAO]

I  do not know.
JCH MD

[flossy93]

Thanks so much for the comment that 7-MX may be available under an FDA experimental protocol!

Do you know if it is for use in children and adolescents only, or can adults also be considered for use in the FDA testing?

[flossy93]

If you are searching for 7-MX to help slow development of myopia you have probably already read about Dr. Klaus Trier and his study regarding efficacy of this supplement in children and adolescents.  If not, here is a link to his website where he describes his results:  http://klaustrier.dk/english/myopia/

Here is a link to the actual study published by Dr. Trier:  
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802512/

I have not found any evidence that this supplement has been approved for use in the USA (although many supplements are not 'approved' in the US, it sounds as though no one is dispensing pharmaceutical-grade 7-MX in the US.  

It sounds like any patients who want to obtain must go to Denmark to consult with Dr. Trier.  I don't know if it is possible to get the capsules from Dr. Trier directly via mail without his seeing your children in person. Or if there are others clinics or doctors elsewhere in Europe where the supplement can be obtained from Denmark and then forwarded to the US.

Given the apparent efficacy of the supplement and its apparent lack of side effects, it is surprising to me that its use hasn't become more widespread or that it isn't easier to obtain.  I can understand why you want to try it for your boys.  

Good luck with your search.  If you have any luck, please let others here on the forum know what you found out.  Thank you.  

[John C Hagan III, MD, FACS, FAAO]

The medication is provided under a FDA experimental protocol.  You will need to do an internet search about organizations or physicians that have access to the medication.

JCH MD