There are genetic abnormalities associated with blue sclera and might represent Ehler-Danlos syndrome. This can be autosomal recessive and involve abnormalities in the gene for lysyl hydroxylase. I would definitely recommend evaluation by an eyeMD as well as geneticist to determine the defect. Another condition, it can be associated with corneal condition known as keratoglobus, joint hyperextensibility and blue sclera but normal lysyl hydroxylase.
Sandy T. Feldman, M.D., M.S.
ClearView Eye and Laser Medical Center
San Diego, California
Many thanks for your reply I will get this looked into.