problems in my central vision of 1 eye

[bide]

Dear Doctor. Some days after start using Celebrex I noted a loss of vision in the central area of the vision in one eye. I cant read a letter that I was looking at, but I can see the letters in both sides of the letter I was looking. If I look with that eye to a white wall I can see a yellow circle sorrounding another smaller white circle. I stoped to use Celebrex about a week ago but the only thing is happening is that the yellow circle is increasing size in the direction of the center of the white circle. Depending in the level of illumination and the angle I look to the wall, I can see a image of a  small spot exactly in the center of the vision, that has the form of a bean, inside of what I can see a series of smaler spots of yelow color. I am sure I dont have macular degeneration: five days before I started to use Celebrex I have gone to a ophtalmologist to rotine examination. In that day my vision was perfect: the visual test for glasses presented no problems. Do you think there could be a relation between my problem an the use of Celebrex? I hope you could undertand my poor English. Best Regards, Alcibiades.

[Ray T Oyakawa, MD]

You are correct.  I have had patients on Celebrex and NSAID develop fluctuating vision. However,  it is best to be safe and get you macular checked with an OCT.  There many cause of loss of central vision.

Dr. O.

[bide]

Dear Dr Oyakama, I thank you very much for your response. THe reason of my question was due to several medical I found in medical reports. In case you are interested please take a look. Best Regards, Alcibiades

http://www.drugs.com/sfx/celebrex-side-effects.html
Ocular
The case of orange spots and case of jellybean-like area of vision loss centrally resolved within 72 hours of discontinuing the drug.Ocular side effects including blurred vision, cataracts, conjunctivitis, and eye pain have been reported in less than 2% of patients. Vitreous floaters and conjunctival hemorrhage have been reported in 0.1% or greater to less than 1% of patients. At least one case of orange spots has also been reported, in addition to a case of jellybean-like area of vision loss centrally.
Read more: http://www.drugs.com/sfx/celebrex-side-effects.html#ixzz0pRrR4pQA
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PDF (95 KB) | PDF Plus (154 KB)
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http://www.farmacovigilancia.sld.cu/visual.htm

A plausible mechanism exists
There is evidence that the cyclo-oxygenase enzymes COX-1 and COX-2 are involved in the regulation of retinal blood flow.7 Interference with the action of these enzymes by either COX-2 inhibitors or conventional NSAIAs may therefore cause acute, temporary disturbance of vision. The clinical picture seen in the reported cases is consistent with this mechanism, although there may be other possible explanations.

Case 2: A man aged 81 was taking celecoxib 100mg daily following knee replacement surgery for osteoarthritis. Three weeks after commencing celecoxib he developed jellybean-shaped loss of vision centrally in each eye. This occurred every day after his morning dose and lasted for a few hours. The celecoxib was stopped and there was no recurrence of the visual disturbance.
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[Ray T Oyakawa, MD]

It may be unrelated.  This is some type of macular problem.  See an EyeMD.

Dr. O.