My story is long, but I will try to sumarize. I am very suspitious of lyme disease. I need to know how to find out with relative assurance that I do not have it. I have talked with a few people that do and also read a lot of information online and I'm not sure what to listen to and what not to. If I go online to a "symptoms" list and look at the 60 or so possible symptoms I generaly experience at least 50% of them. I'm a 34 yr old single male. I had a deep unexplained depression come over me about 6 years ago, along with a large number of eye floaters almost overnight. I am loosing my hair fast (prabably male pattern baldness according to a dermatologist) and I have very dry eyes, and chronic sinusitis came over me about 6 years ago too. I can't remember off the top of my head some of the other small symptoms that I connected with the "list", but my biggest concern came about 9 months ago when I had promiscuous sex and ended up with a urinary tract infection. I did learn my lesson, but the first one-day antibiotic didn't knock it out so my doctor put me on 30 of 200mg Doxycicline. I have never experienced such horror in my life. My anxiety went through the roof, all of the lymph nodes in my body (neck, arms, armpits, groin) were painful and sweating, night sweats, severe muscle pain/stiffness, eyes ached, rashes, little red pin dots on my skin, and just a feeling of terrible mallice. I thought I had a serious STD, but at 5 months out everything came back negative. I was complaining a lot about my lymph node pain and so the doc ordered lupus, mono and lyme disease blood tests, all came back neg. He was ready to send me to a onocologist, but did a leukimia screen which came back neg so he stopped at that and just put his hands up. Well all of these symptoms went away VERY gradually over the next 6 months after I finished the doxycycline, so I was releaved, but I still get a little lymph node discomfort and muscle stiffness on a regular basis and now in the past month my left knee joint is acting a little stiff and swollen at times. My ther things like sinusitis and eye issues still continues. This is something I haev never had before...and I know that is a major symptom of lyme. I have also heard that the standard blood test is inacurate over 50% of the time, and I read about some article that was explaining that sometimes when you take an antibiotic and you have severe reactions like that it can indicate an underlying infection or something else in your system that is being killed off and releasing toxins that cause the symptoms. Basically it was saying that that kind of reaction could indicate a disease like lyme or syphilis or something. This has all been very strange and upsetting to me and I need to find out where I am at and how to know for sure if I do or do not have Lyme disease. Someone told me I should do a PCR test for it? Any advise or opinion about my situation would help. My family doctor is not much help. Thanks.