I have fibromyalgia, degenerative arthritis and yes, clinical depression. When I take Savella and Pristiq together, it works wonders. When both my pain dr and my psychiatrist got together and said I couldn't take them together, I became very depressed after getting off of Savella. I didn't want to kill myself, but I sure didn't want to live. Lyrica put me to sleep in horrible ways, Cymbalta doesn't work for me and anything like Prozac or Lexapro or Zoloft is candy to me. I also take Norco. But I WANT to take Savella and Pristiq together because FOR ME it works...why do they say I can't???? I am calling my psychiatrist today, cause I cannot take this feeling anymore. I've taken pretty much everything. I've not taken mobic, I have a friend that says it is good, but she doesn't have depression. I also hold down a full time job. Thank you and you all have a blessed day.